摘要
目的研究小剂量阿司匹林对妊娠期高血压患者24 h尿蛋白定量的影响。方法将纳入的180例妊娠期高血压患者随机分为3组:对照组,阿司匹林50 mg/d组、100 mg/d组,每组60例,从孕16周开始直至分娩前,对比三组的临床效果。结果三组患者平均动脉压、子痫前期发生率、分娩孕周和剖宫产率比较差异无统计学意义(P>0.05)。治疗后,50 mg/d组24 h尿蛋白定量和血清内皮素-1(ET-1)水平低于其他两组,而超氧化物歧化酶(SOD)水平较高,差异有统计学意义(P<0.05)。三组间胎儿围生期并发症发生率比较差异无统计学意义(P>0.05)。结论阿司匹林50 mg/d可降低妊娠期高血压患者24 h尿蛋白定量、血清ET-1水平,提高SOD水平,但是否改善母婴分娩结局还有待进一步研究。
Objective To study the effect of low-dose aspirin on 24 h urinary protein in gestational hypertension patients. Methods A total of 180 gestational hypertension patients were enrolled and divided randomly into control group,aspirin 50 mg/d group and aspirin 100 mg/d group,60 cases in each group. The clinical efficacy of the patients in 3 groups was compared from 16 th week of pregnancy to delivery. Results There was no significant difference in the mean arterial pressure,pre-eclampsia incidence,gestational weeks or cesarean section rate among the three groups（ P〉0. 05）. The levels of 24 h urinary protein and serum endothelin-1（ ET-1） in aspirin 50 mg/d group were lower than those of the other groups,while the superoxide dismutase（ SOD） level was higher（ P〈0. 05）. No significant difference was found in the rate of fetal perinatal complications among the three groups（ P〉0. 05）. Conclusion Aspirin50 mg/d can reduce the levels of 24 h urinary protein and serum ET-1 levels,and increase the SOD level of patients with gestational hypertension. It needs further study whether it can improve maternal and fetal delivery outcomes.
出处
《实用药物与临床》
CAS
2018年第2期175-178,共4页
Practical Pharmacy and Clinical Remedies
