摘要
目的:探讨盆腔超声在促性腺激素释放激素类似物(GnRHa)治疗特发性中枢性性早熟(ICPP)女童中的参数特征及其临床价值。方法:选取2013年11月至2016年6月榆林市第一医院31例ICPP患者设为研究组,另选取同期性发育检查正常女童31例设为对照组。所有受检者均接受盆腔超声检查,同时研究组接受GnRHa治疗,共治疗3个月,并于入院时及疗程结束后以全自动荧光免疫分析系统检测血清性激素雌二醇(E_2)、促卵泡素(FSH)、黄体生成素(LH)水平。统计对比两组盆腔超声检查相关参数(子宫长径、子宫体积、卵巢面积、卵巢体积、卵泡最大直径、卵泡数目、子宫内膜厚度)、研究组治疗前后盆腔超声检查相关参数及治疗前后血清性激素(E_2、FSH、LH)水平变化情况。结果:研究组子宫长径、子宫体积、卵巢面积、卵巢体积、卵泡最大直径、卵泡数目、子宫内膜厚度大于对照组,差异有统计学意义(P<0.05)。研究组治疗后子宫长径、子宫体积、卵巢面积、卵巢体积、卵泡最大直径、卵泡数目、子宫内膜厚度均较治疗前减小,差异有统计学意义(P<0.05)。治疗后研究组血清E_2、FSH、LH水平低于治疗前,差异有统计学意义(P<0.05)。结论:盆腔超声可对ICPP进行无创性、准确诊断,且能动态监测促性腺激素释放激素类似物治疗特发性中枢性性早熟女童的效果,为进一步干预方案的制定提供参考依据,具有推广价值。
Objectives： To investigate the parameters and clinical value of pelvic ultrasound in gonadotropin-releasing hormone analogues（ GnRHa） on idiopathic central precocious puberty（ ICP）. Methods： From January2013 to June 2016,31 patients with ICPP in the first hospital of Yulin were selected as the study group,and 31 normal subjects were selected as the control group. All subjects received pelvic ultrasonography,while the study group received GnRHa treatment,all for 3 months. The serum estradiol（ E2）,follicle stimulating hormone（ FSH） and luteinizing hormone（ LH） levels were measured by automatic immunoassay system at the time of admission and after treatment. Pelvic ultrasound related parameters（ uterine diameter,uterine volume,ovarian area,ovarian volume,follicular diameter,follicle number,endometrial thickness）,the parameters of pelvic ultrasonography before and after treatment in the study group,the serum sex hormones（ E2,FSH,LH） before and after treatment were statistically compared between the two groups. Results： The uterine diameter,uterine volume,ovarian area,ovarian volume,follicular diameter,follicle number and endometrial thickness of the study group were significantly higher than those of the control group（ P〈0. 05）. The diameter of uterus,uterine volume,ovarian area,ovarian volume,follicular diameter,follicle number and endometrial thickness of the study group after treatment were significantly lower than those before treatment（ P〈0. 05）. The levels of serum E2,FSH and LH in the study group after treatment were significantly lower than those before treatment（ P〈0. 05）. Conclusion： Pelvic ultrasonography can be used for noninvasive and accurate diagnosis of ICPP,and can dynamically monitor the effect of gonadotropin-releasing hormone analogue in the treatment of idiopathic central precocious puberty girls,which can provide reference for the further intervention plan and worth promotion.
出处
《中国性科学》
2018年第2期60-63,共4页
Chinese Journal of Human Sexuality
基金
陕西省科学技术研究发展计划项目(2012K16-09-03)
关键词
盆腔超声
促性腺激素释放激素类似物
特发性中枢性性早熟
参数特征
Pelvic ultrasonography
Gonadotropin - releasing hormone analogue
Idiopathic Central preco-cious puberty （ICPP）
