摘要
目的:探索平均血小板体积(MPV)对慢性阻塞性肺疾病(COPD)急性加重期呼吸衰竭患者的意义。方法:选取2015-04-01-2016-11-01期间就诊于我院急诊科的COPD急性加重期呼吸衰竭患者92例,其中Ⅰ型呼吸衰竭51例,Ⅱ型呼吸衰竭41例。所有患者在入院后立即查血常规、C反应蛋白(CRP)、血气分析。同时有40名健康体检者作为对照组,年龄、性别、体重指数(BMI)、吸烟史与研究组匹配。比较各组MPV、血常规、血气等各参数关系。结果:Ⅰ型呼吸衰竭组MPV(10.6±1.3)及Ⅱ型呼吸衰竭组MPV(10.1±1.6)显著高于对照组MPV(8.9±0.8);MPV与PO2有明显相关性(r=0.440,P<0.01),MPV与乳酸有明显相关性(r=0.430,P<0.01);MPV与白细胞计数(WBC)有弱相关性(r=0.218,P<0.05),MPV与中性细胞百分比、CRP、PCO2、PH值、血红蛋白、红细胞压积及血小板计数均无明显相关性。结论:在COPD急性加重期呼吸衰竭患者中,MPV升高可以反映患者缺氧及组织低灌注情况,MPV与炎症指标相关性不显著。
Objective：To explore the significance of mean platelet volume（MPV）in patients with respiratory failure due to acute exacerbation of chronic obstructive pulmonary disease.Method：Ninty-two patients patients with respiratory failure due to acute exacerbation of chronic obstructive pulmonary disease were eligible to be enrolled from April 1 st,2015 to November 1 st,2016 in emergency treatment of XUANWU hospital,including 51 cases of type I respiratory failure,41 cases with type Ⅱ respiratory failure.Routine blood test,C reactive protein（CRP）and blood gas analysis were made immediately after admission.At the same time,40 healthy people were served as controls,with age,sex,body mass index（BMI）,smoking history matched with the study group.The relationship of MPV,blood routine,blood gas and other parameters in each group was compared.Result：MPV of typeⅠ respiratory failure group（10.6±1.3）and type Ⅱ respiratory failure group（10.1±1.6）were significantly higher than the MPV of control group（8.9±0.8）;there was significant correlation between MPV and PO_2（r=0.440,P〈0.01）;There was significant correlation between MPV and lactic acid（r=0.430,P〈0.01）;MPV and white cell count（WBC）had weak correlation（r=0.218,P〈0.05）;There were no significant correlation between MPV and CRP,PCO_2,neutrophil percentage,pH,hemoglobin,hematocrit and platelet counts.Conclusion：In patients with respiratory failure due to acute exacerbation of COPD,elevated MPV may reflect hypoxia and low tissue perfusion,and there is no significant correlation between MPV and inflammatory markers.
出处
《临床急诊杂志》
CAS
2017年第12期942-945,共4页
Journal of Clinical Emergency
关键词
慢性阻塞性肺疾病
呼吸衰竭
平均血小板体积
乳酸
chronic obstructive pulmonary disease
respiratory failure
mean platelet volume
lactic acid
