摘要
目的：分析脓毒症患者采用中医辨证疗法进行治疗的临床效果。方法：脓毒症患者80例,参考随机双盲分组法将全部患者随机分成两组：对照组共有40例,行西医常规临床治疗;观察组共有40例,在对照组的基础上加用中医辨证疗法联合治疗。两组患者均连续治疗1周,1周后对两组患者治疗后的疗效进行评估分析,且观察治疗前、后两组患者的中医症状积分、APACHEⅡ评分及炎症因子变化。结果：治疗后观察组的总有效率70%,显著高于对照组的47.5%,差异有统计学意义,（χ~2=10.444,P〈0.05）,观察组治疗后的中医症状积分（4.98±1.09）分、APACHEⅡ评分（9.39±2.18）分,显著低于对照组的相应指标,差异有统计学意义（P〈0.05）,观察组治疗后的TNF、IL-6、IFN-γ、IL-4分别为（6.98±1.11）pg/m L、（1.04±0.47）pg/m L、（49.83±7.62）pg/m L、（13.28±4.29）pg/m L,显著低于治疗前及对照组治疗后相应指标,差异有统计学意义（P〈0.05）。结论：脓毒症患者的采用中医辨证疗法进行治疗疗效显著,值得临床借鉴推广。
Objective： To analyze the clinical effect of TCM syndrome differentiation therapy in patients with sepsis.Methods： Eighty patients with sepsis were randomly divided into 2 groups with reference random double blind method： the control group 40 cases（ conventional western medicine for clinical treatment）; the observation group 40 casesi（ adding traditional Chinese medicine differentiation therapy）. Two groups were treated for 1 week and then two groups were assessed the efficacy,TCM symptoms score,APACHE II score and the changes in inflammatory factors. Results： Total efficiency was 70% in the observation group after treatment,significantly higher than 47. 5% in the control group. The difference was statistically significant（ χ~2= 10. 444,P 0. 05）. The TCM symptom score of the treatment group was（ 4. 98 ±1. 09） and APACHE score（ 9. 39 ± 2. 18） %,significantly lower than those in the control group. There were statistically significant differences（ P 0. 05）. After treatment,the observation group＇s TNF,IL-6,IFN-γ and IL-4 were respectively（ 6. 98 ± 1. 11） pg/m L,（ 1. 04 ± 0. 47） pg/m L,（ 49. 83 ± 7. 62） pg/m L and（ 13. 28 ± 4. 29） pg/m L,significantly lower than those before treatment and control group＇s corresponding indexes. The difference was statistically significant（ P 0. 05）. Conclusion： The treatment of sepsis patients with TCM syndrome differentiation therapy has significant curative effect and it is worthy of clinical use.
出处
《中华中医药学刊》
CAS
北大核心
2018年第3期726-728,共3页
Chinese Archives of Traditional Chinese Medicine
基金
浙江省医学会项目(2015ZYC-A103)
关键词
脓毒症
中医
辨证治疗
疗效
sepsis
traditional Chinese medicine
treatment based on syndrome differentiation
curative effect
