摘要
目的分析糖皮质激素不同给药途径、不同剂量治疗甲状腺功能亢进(GD甲亢)初发和复发者的临床疗效及安全性。方法随机抽取108例甲状腺功能亢进患者作为研究对象,按用药方式的不同,有36例患者接受40 mg/d甲基强的松龙治疗(A组),有36例患者接受30 mg/d强的松治疗(B组),有36例患者接受15 mg/d强的松治疗(C组),治疗2周或,对各组患者的临床效果进行统计对比,并评价其用药安全性。结果治疗后,各组患者治疗后的FT3、FT4指标较治疗前有所减低,(P<0.05)有统计学意义,但各组患者治疗后的FT3、FT4指标比较差异不明显,(P>0.05)无统计学意义;各组患者甲状腺功能改善有效率与对照组比较差异不明显,(P>0.05)无统计学意义;本组肝功能损害A组患者32例,B组患者21例,C组患者15例,A、B两组患者与C组肝功能改善有效率比较差异明显,(P>0.05)有统计学意义;但A、B两组有效率比较差异不明显,(P>0.05)无统计学意义。结论对甲状腺功能亢进患者的治疗,采取糖皮质激素可改善患者的临床症状,降低甲状腺功能水平,且用药安全,在临床中具有良好的应用价值。
Objective To analyze the clinical efficacy and safety of different doses of glucocorticoid in the treatment of primary and recurrent hyperthyroidism（GD hyperthyroidism）. Methods 108 cases of hyperthyroidism patients were randomly selected as the research object. According to the different treatment methods, 36 cases of patients were received 40 mg/D methylprednisolone therapy（group A）. 36 cases of patients were received 30 mg/D prednisone therapy（group B）. 36 cases of patients were received 15 mg/D prednisone treatment（group C）. All cases were treated for 2 weeks, the clinical effect of patients in each group were compared statistically, and the safety of drugs was evaluated. Results after the treatment, FT3, FT4 index in each group of patients decreased compared with those before treatment（P〈 0.05）, which was statistically significant, but serum FT3, FT4 indexes in all groups after treatment did not differ significantly（P 〉 0.05）.There were no statistical significance among all groups of patients in thyroid function,（P 〉 0.05）. In group A, there were 32 cases with damage of liver function, group B had 21 cases with damage of liver function, and group C had 15 cases. There were significant difference in improvement of liver function between group A, B and group C（P 〉 0.05）, but the difference between A and B was not obvious（P 〉0.05）. Conclusion In the treatment of hyperthyroidism, glucocorticoid can improve the clinical symptoms of patients, reduce thyroid function, and it is safe. So it has good application value in clinical practice.
出处
《新疆医学》
2017年第12期1370-1372,共3页
Xinjiang Medical Journal
