摘要
目的在常规治疗基础上，观察加用不同剂量螺内酯治疗难治性高血压的临床效果。方法选择20152017年昌图县第二医院收治的难治性高血压患者73例，随机分为高剂量组37例和低剂量组36例。两组均采用氢氯噻嗪25mg／d、非洛地平5mg／d、培哚普利4mg／d口服，低剂量组加用螺内酯20mg／d；高剂量组加用螺内酯40mg／d，两组均治疗1个月后评价疗效。结果高剂量组各血压观察指标均优于低剂量组，组间差异有统计学意义（P〈0．05）。结论在常规治疗基础上加用不同剂量螺内酯治疗难治性高血压均可获得不错的效果，而且降压效果和剂量有一定关系。
Objective To observe the effects of different doses of spironolactone on refractory hypertension based on conventional therapy- Methods A total of 73 cases of refractory hypertension patients from 2015 to 2017 were collected and randomly divided into high dose group （37 cases） and low dose group （36 cases）. Both groups were treated with hydrochlorothiazide （25 mg/d）, felodipine （5 mg/d） and perindopril （4 mg/d）. Additionally, low dose group was treated with spironolactone （20 mg/d）, while high dose group was treated with spironolactone （40 mg/d）. Then, we compared the curative effects after a one-month treatment. Results The blood pressure indexes in high dose group were significantly better than those in low dose group （P〈0.05）. Conclusion Based on conventional therapy, the spironolactone can provide a good curative effect on refractory hypertension. Moreover, the antihypertensive effect was associated with different doses of spironolactone.
出处
《中国实用乡村医生杂志》
2018年第2期38-39,42,共3页
Chinese Practical Journal of Rural Doctor
关键词
高血压
难治性
螺内酯
效果
Hypertension
Refractory
Spironolactone
Effect
