摘要
目的探索体重指数(BMI)对正常人群的成年男性血清前列腺特异性抗原(PSA)水平的影响。方法收集2015年01月至2016年12月在西安交通大学第一附属医院体检中心进行健康体检者的资料,筛选所有年龄、身高、体重、血清总PSA水平数据完整的成年男性体检者。计算BMI并根据BMI中国标准将研究对象分为偏瘦(BMI<18.5kg/m^2)、正常(BMI 18.5~23.9kg/m^2)、偏胖(BMI 24.0~27.9kg/m^2)、肥胖(BMI≥28kg/m^2)4组;按照年龄分为18~29、30~39、40~49、50~59、60~69、70~79、≥80岁7组,方差分析分别比较各BMI组内PSA水平的差异。结果共收集资料完整者共15 830例,平均年龄(50.87±14.07)岁;平均BMI(25.19±3.11)kg/m^2;平均PSA(1.18±1.04)ng/mL。血清PSA在18~29、30~39、40~49岁组基本保持不变,之后随年龄增长而增加。偏瘦、正常、偏胖及肥胖组PSA分别为(1.42±1.29)、(1.28±1.13)、(1.14±0.98)及(1.03±0.95)μg/L,PSA水平随BMI增加而显著降低。在30~39和40~49岁年龄组内,总PSA水平随BMI升高而降低最为显著。结论血清总PSA在50岁后随年龄增长增加明显;血清总PSA随着BMI的增加而降低,这一趋势在30~39和40~49岁年龄组最为显著。
Objective To investigate the relationship between body mass index （BMI） and serum prostate-specific antigen （PSA） level in adult males.Methods The health examination data of adult males were collected during Jan.2015 and Dec.2016,including the age,height,weight,and serum PSA level.The subjects were categorized as underweight（BMI〈18.5 kg/m^2）,normal （BMI 18.5-23.9 kg/m^2）,overweight （BMI 24.0-27.9 kg/m^2）,and obese（BMI≥28.0 kg/m^2）.The subjects were divided into 7 groups based on the age：18-29,30-39,40-49,50-59,60-69,70-79 and ≥80 year old groups.The PSA levels were stratified by BMI category for statistical analysis.Results A total of 15,830 adult males were included,mean age（50.87±14.07）years,mean BMI（25.19±3.11）kg/m^2,and mean PSA（1.18±1.04）μg/L.The PSA level was stable before the subjects were 50 years old,and then increased with age.The PSA in the underweight,normal,overweight,and obese groups were （1.42±1.29）,（1.28±1.13）,（1.14±0.98） and （1.03±0.95）μg/L,respectively,which decreased significantly with the increase of BMI,and this negative correlation was more significant in the 30-39 and 40-49 year old groups.Conclusion The PSA level increases with age after the subjects are 50 years.There is a negative correlation between BMI and PSA,especially in the 30-39 and 40-49 year old groups.
出处
《现代泌尿外科杂志》
CAS
2018年第3期187-189,223,共4页
Journal of Modern Urology
关键词
体重指数
前列腺特异性抗原
正常人群
肥胖
body mass index
prostate specific antigen
normal population
obesity
