摘要
目的观察右美托咪定对七氟醚麻醉下神经外科手术苏醒期的影响。方法择期行神经外科手术患者60例,随机分为右美托咪定组(DEX组)和对照组(C组),每组30例。DEX组于麻醉诱导前20 min静脉输注右美托咪啶0.5μg/kg,随后以0.1μg/(kg·h)静脉输注至手术结束前30 min;C组给予等容量生理盐水。记录麻醉前(T_0)、拔管即刻(T_1)和拔管后10 min(T_2)时的MAP、HR和SpO_2;记录睁眼时间、T_1时的躁动评分、T_2时的镇静评分和疼痛程度评分,记录苏醒期不良反应的发生。结果与T_0相比,C组患者MAP在T_1时刻升高,HR在T_1、T_2时刻均升高;DEX组患者MAP在T_1时刻升高,HR在T_1时刻升高;与C组相比,DEX组的MAP在T_1降低,HR在T_1、T_2时刻均降低(P<0.05)。两组患者躁动评分、VAS评分及Ramsay评分组间比较差异有统计学意义(P<0.05)。结论右美托咪定能够减少神经外科手术应用七氟醚苏醒期躁动的发生,使得苏醒期更加平稳,值得在临床上使用。
Objective To investigate the effect of dexmedetomidine in the sevoflurane anaesthesia in recovery period of neurosurgery. Methods Sixty patients undergoing neurosurgery were randomly divided into two groups（ 30 patients for each group） ： DEX group were received 0. 05 mg/kg of dexmedetomidine before introduction in 20 minutes and then continue with 0. 1μg/（ kg·h） until 30 min before the end of the surgery and equal volume saline respectively in group C.Record MAP,HR and SpO_2 before induction of anesthesia（ T_0）,the moment of extubation（ T_1） and 10 min after intubation（ T_2）. Awaken time,Agitation score,Ramsay,VAS scores and adverse reactions of the two groups were observed and recorded. Results Compared to T_0,MAP increased at T_1 and HR increased at T_1 and T_2 in group C; MAP increased at T_1 and HR increased at T_1 in group DEX. Compared to group C,MAP decreased at T_1 and HR increased at T_1 and T_2（ P 〈0. 05）. There is statistically significant difference in Agitation score,VAS and Ramsay scores between the two groups. Conclusion Dexmeditomidine could effectively reduce agitation in patients with sevoflurane aneaesthesia in recovery period of neurosurgery and it is a better choice in clinical.
出处
《医药论坛杂志》
2018年第1期32-34,共3页
Journal of Medical Forum
关键词
右美托咪定
神经外科
七氟醚
术后躁动
Dexmeditomidine
Neurosurgery
Sevoflurane
Postoperrative agitation
