摘要
目的研究变应性鼻炎患者鼻分泌物嗜酸性粒细胞(eosinophils,Eos)分布特点和血清特异性IgE(specific IgE,sIgE)滴度的关系,评价鼻分泌物Eos细胞学检查对变应性鼻炎辅助诊断价值。方法选取2016年1月~2017年6月北京中医医院顺义医院耳鼻咽喉科门诊变应性鼻炎患者60例,同期非变应性鼻炎患者60例和30例正常者作为对照组。所有受试者进行鼻分泌物涂片Eos细胞学检测和血清sIgE检测,分析各组鼻分泌物Eos分布特点和血清sIgE的关系。结果鼻分泌物Eos分布程度与血清sIgE水平呈一致性(κ=0.264,P=0.000),具有统计学意义;鼻分泌物Eos的ROC曲线下面积为0.881,标准误差为0.025,95%置信区间为0.841~0.924;当鼻分泌物Eos涂片分级为3级时,ROC曲线尤登指数最大,其敏感度为88.5%,特异性为99.4%。结论鼻分泌物Eos细胞学检测对变应性鼻炎诊断有一定的辅助价值,便宜简洁快速,可作为基层医院诊断变应性鼻炎的有效参考指标。
OBJECTIVE To invest igate the relationship between the distribution of eosinophils（Eos） of nasal secretion and serum specific IgE（sIgE） titer in patients with allergic rhinitis, and to evaluate the diagnostic value of Eos in nasal secretion for allergic rhinitis. METHODS A total of 60 allergic rhinitis patients from Department of Otolaryngology, Beijing Shunyi Hospital of Traditional Chinese Medicine during Jan. 2016 to June 2017 were selected as treatment group, and another 60 cases of non-allergic rhinitis and 30 normal persons in the corresponding time period were chosen as control group. Eos in nasal secretions and serum sIgE were measured in all the subjects and the relationship between Eos distribution and serum sIgE level was analyzed. RESULTS The Eos distribution and serum level of sIgE was consistent（κ=0.264, P =0.000） and statistical significance was found. The area of ROC of the Eos in nasal secretion was 0.881, the standard deviation was 0.025 and95% confidence interval was 0.841 to 0.924. The Udden index of ROC reached the maximum when the Eos in nasal secretion smear was graded as level 3, the sensitivity was 88.5% and specificity was 99.4%. CONCLUSION Eos cytological examination of nasal secretions has some auxiliary value in the diagnosis of allergic rhinitis. It is a cheap, simple and rapid method, which can be used as an effective reference index for diagnosing allergic rhinitis in primary hospital.
出处
《中国耳鼻咽喉头颈外科》
CSCD
2018年第2期89-92,共4页
Chinese Archives of Otolaryngology-Head and Neck Surgery
基金
国家自然基金面上项目(81674034)
北京市自然基金面上项目(7162081)
首都卫生发展研究专项(2016-2-2231)
首都中医药课题专项重点课题(16ZY05)联合资助
