摘要
目的探讨奥美拉唑联合雷贝拉唑对慢性萎缩性胃炎患者血清胃蛋白酶原(PGⅠ、PGⅡ和PGR)及胃泌素-17(G-17)水平的影响。方法选取2016年3月至2017年3月我院收治的慢性萎缩性胃炎患者86例,随机分为对照组和试验组,每组43例。所有患者均采用阿莫西林、克拉霉素及养胃颗粒进行常规治疗,对照组在此基础上加用奥美拉唑,试验组则加用奥美拉唑和雷贝拉唑,疗程为8周。治疗后比较两组患者的临床效果、血清胃蛋白酶原和G-17水平。结果试验组总有效率为93.02%,明显高于对照组的76.74%(P<0.05);治疗后,两组患者的PGⅠ、PGR、G-17水平均升高(P<0.05),且观察组PGⅠ、PGR、G-17水平高于对照组(P<0.05)。结论奥美拉唑联合雷贝拉唑治疗慢性萎缩性胃炎临床效果显著,能有效提高胃蛋白酶及G-17水平,明显改善患者的临床症状和体征,减轻胃黏膜的炎症反应,可阻止癌前病变的进一步发生,此治疗方案行之有效,值得临床推广应用。
Objective To discuss the influence of omeprazole combined with rabeprazole on the levels of pepsinogen（PG Ⅰ, PG Ⅱ and PGR） and gastrin-17（G-17） in serum of chronic atrophic gastritis patients. Methods Eighty-six patients with chronic atrophic gastritis admitted in our hospital from March 2016 to March 2017 were selected and randomly divided into control group and experimental group, with 43 patients in each group. All the patients were treated with routine treatment including amoxicillin, clarithromycin and Yangwei particles, while patients in the control group were treated with omeprazole additionally, and patients in the experimental group used omeprazole and rabeprazole based on the routine treatment. The course of treatment was 8 weeks. After treatment, the clinical effects and levels of pepsinogen and G-17 in serum were analyzed and compared between the two groups. Results After treatment, the total effective rate of the experimental group was 93.02%, which was higher than 76.74% of the control group（P 0.05）. After treatment, the levels of PG Ⅰ, PGR and G-17 in the two groups increased, and those of the experimental group were higher than the control group（ P 0.05）. Conclusion The clinical effect of omeprazole combined with rabeprazole in patients with chronic atrophic gastritis is remarkable. It can significantly improve the levels of pepsinogen and G-17, improve the clinical symptoms and signs of the patients, alleviate the inflammatory reaction of gastric mucosa, and prevent the further occurrence of precancerous lesions. It is an effective treatment methods, which is worthy of clinical application.
出处
《临床医学研究与实践》
2018年第4期6-7,10,共3页
Clinical Research and Practice
