摘要
目的探讨血清胃蛋白酶原Ⅰ(PGⅠ)、Ⅱ(PGⅡ)水平及其比值(PGR)对胃癌早期筛查的诊断效能。方法收集本院2016年1月-2016年9月收治的胃溃疡患者45例,萎缩性胃炎患者42例,不典型增生患者28例,胃癌患者61例作为研究病例,同时选取60例体检健康者作为对照组,所有受试者均采用微粒子化学发光法定量检测血清样本中的PGⅠ、PGⅡ水平,并计算PGR值。结果(1)与对照组比较,胃溃疡组PGI、PGⅡ水平均明显升高(P<0.05),PGR降低(P<0.05)差异有统计学意义;萎缩性胃炎组,不典型增生组及胃癌组PGI、PGR均明显降低(P<0.05),PGⅡ水平升高(P<0.05),差异有统计学意义。(2)PGI、PGⅡ、PGRROC曲线下面积分别为0.873,0.497,0.848,PGI、PGR对胃癌的诊断价值较高。(3)PGI≤64.8 ng/mL时诊断胃癌敏感度90.4%,特异度75.6%,PGR≤3.7时诊断胃癌敏感度95.5%,特异度70.8%。结论血清PGⅠ水平及PGR值对诊断胃癌有较高的敏感性和特异性,可用于胃癌筛查和早期诊断。
Objective To Evaluate the diagnostic effect of Pepsin Ⅰ、Pepsin Ⅱ and the ratio for gastric cancer. Methods 45 patients with gastric ulcer,42 patients with Atrophic gastritis,28 patients with atypical hyperplasia and 61 patients with gastric cancer as case study. 60 healthy physical examination personnel as the control group. All the people were selected from our hospital from January2016 to September 2016. All the subjects were quantitative test pepsinⅠand pepsin Ⅱusing particles chemiluminescence immunoassay,calculating PGR. Results Compared with the control group, PGI and PGⅡ were significantly higher in gastric ulcer group than that of the control group（P〈0.05） and PGR were lower（P〈0.05）,the difference was statistically significant; PGR and PGI were significantly lower than atrophic gastritis, atypical hyperplasia and gastric cancer（P〈0.05）and PGⅡ was higher（P〈0.05）, the difference was statistically significant. The AUC of serum PGI, PGⅡ and PGR in the diagnosis of gastric cancer were 0.873, 0.497, 0.848, PGI, PGR higher value to the diagnosis of gastric cancer. PGI≤64.8 ng/mL,the sensitivity to diagnose gastric cancer was 90.4%, the specificity was 75.6%, PGR≤3.7, the sensitivity to diagnose gastric cancer was 95.5%, the specificity was 70.8%. Conclusions It has higher sensitivity and specificity of PGI and PGR for the diagnostic of gastric cancer, it can be used for screening and early diagnosis of gastric cancer.
出处
《新疆医学》
2018年第1期30-32,共3页
Xinjiang Medical Journal
基金
新疆医科大学科研创新基金项目(XYDCX201464)
关键词
胃蛋白酶原
胃癌
效能评价
Pepsin
Gastric Cancer
Effectiveness Evaluation
