摘要
目的分析登革热患儿血小板参数的变化特点,探讨其在登革热诊治、预后中的应用价值。方法分析69例登革热患儿急性发热期及缓解期血小板参数的变化情况,并与103例健康对照组儿童进行比较,通过比较肝功能损伤组与肝功能正常组,凝血功能异常组与凝血功能正常组,重症组与轻症组登革热患儿之间血小板参数的差异,探讨登革热患儿血小板减少的原因,了解骨髓生成血小板的情况。结果登革热患儿急性发热期组大血小板比率(P-LCR)、血小板体积分布宽度(PDW)、血小板平均体积(MPV)明显高于健康对照组(P<0.01),血小板压积(PCT)、血小板计数(PLT)明显降低(P<0.01)。肝功能损伤患儿的MPV明显低于肝功能正常的患儿(P<0.05),其他血小板参数差异无统计学意义(P>0.05);重症组登革热患儿PLT、PCT明显低于轻症组(P<0.05),其他血小板参数差异无统计学意义(P>0.05);凝血功能异常患儿和凝血功能患儿比较,各项血小板参数差异均无统计学意义(P>0.05)。结论血小板参数在儿童登革热的诊治、预后评估中有一定的价值。
Objective To investigate the variation characteristics of peripheral platelet parameters in children with dengue fever and to assess their use and value in diagnosis,prognosis and treatment for dengue fever.Methods Platelet parameters of 69 pediatric patients with dengue fever in acute febrile phase and remission period and 103 healthy controls were compared.The difference of platelet parameters between the liver function injury group and the normal liver function group,the coagulation dysfunction group and the coagulation function normal group,the severe group and the mild group with dengue fever was compared,the causes of thrombocytopenia in children with dengue was investigated so as to better understand the situation of bone marrow producing platelets.Results P-LCR,PDW,MPV were significantly higher in patients in acute febrile phase of dengue fever,compared with the healthy subjects（P〈0.01）,while PCT,PLT were significantly lower in patients in acute febrile phase of dengue fever,compared with the healthy subjects（P〈0.01）.MPV was significantly lower in patients with abnormal hepatic function when compared with patients with normal hepatic function（P〈0.05）,while other platelet parameters did not show significant differences（P〉0.05）.PLT and PCT were significantly lower in the severe patients than those in the mild patients（P〈0.05）,while other platelet parameters did not show significant differences（P〉0.05）.Peripheral platelet parameters did not show significant differences between patients with or without abnormal coagulation function（P〉0.05）.Conclusion Peripheral platelet parameters may play a role in the diagnosis,treatment and prognosis of dengue fever in children.
出处
《国际检验医学杂志》
CAS
2018年第5期562-565,共4页
International Journal of Laboratory Medicine
基金
广东省中医药局资助项目(20151052)
广州市中医药和中西医结合科技项目(20162A011012)
关键词
登革热
血小板参数
预后
dengue fever
platelet parameters
prognosis
