摘要
目的了解2015年甘肃省健康人群肠道病毒71型(EV71)抗体水平,为EV71疫苗的预防接种提供依据。方法于2015年在5个县区按照分层随机抽样方法采集5个年龄组健康人群血清标本,使用微量细胞中和试验检测血清EV71中和抗体。结果调查对象EV71中和抗体阳性率为62.63%(533/851),抗体几何平均滴度(GMT)为1:12.93。0-1岁、2-4岁、5-9岁、10-14岁、≥15岁人群EV7l中和抗体阳性率分别为51.15%、50.90%、58.88%、75.61%、79.87%(X^2=51.52,P〈0.1301),GMT分别为1:7.54、1:12.10、1:12.90、1:20.35、l:16.08(F=4.19,P=0.002)。5个县区人群EV71抗体阳性率在46.00%-83.15%之间(X。=56.70,P〈0.01),GMT在l:6.81-1:20.05之间(F=8.08,P=0.013)。结论2015年甘肃省健康人群EV71抗体水平较低;建议开展重点地区〈5岁儿童EV7l疫苗的接种工作。
Objective To determine enterovirus 71 (EV71) antibody levels of a healthy population in Gansu province in 2015, and to provide evidence for EV71 vaccination. Methods A stratified random sampling was used to select a healthy population, divided into 5 age groups, in 5 counties, for serum sample collection and EV71 antibody detection by micro cell neutralization. Results The positivity rate of EV7I neutralizing antibody was 62.63% (533/851), and the geometric mean titer (GMT) of anti- body was 1: 12.93. Positivity rates among 0-1, 2-4, 5-9, 10-14, and ≥ 15 year olds were 51.15% , 50. 90%, 58.88%, 75.61%, and 79.87%, respectively (X^2 =51.52, P 〈0.001). GMTs were 1:7.54, 1: 12. 10, 1: 12.90, 1:20. 35, and 1: 16.08, respectively (F =4. 19, P =0. 002). Positivity rates in the 5 counties ranged from 46.00% to 83.15% (X2 = 56.70, P 〈 0. 0l), and GMTs ranged from 1 : 6. 81 to 1 : 20. 05 ( F = 8.08, P = 0. 00). Conclusions EV71 antibody levels were relatively low in this healthy population in Gansu in 2015. We recommend EV71 vaccination for 〈5 year old children in priority areas.
作者
陈建华
武海卓
李红育
于德山
Chen Jianhua, Wu Haizhuo, Li Hongyu, Yu Deshan(Gansu Provincial Center for Disease Control and Prevention, Lanzhou 730020, Gansu, Chin)
出处
《中国疫苗和免疫》
北大核心
2018年第1期10-12,共3页
Chinese Journal of Vaccines and Immunization
基金
国家“十二五”艾滋病和病毒性肝炎等重大传染病防治科技重大专项(2012ZX10004-208)
2014年甘肃省卫生行业科研计划管理项目(GWGL2014-75)
关键词
肠道病毒71型
中和抗体
健康人群
Enterovirus 71
Neutralizing antibody
Healthy population