摘要
目的观察贝复舒滴眼液联合玻璃酸钠滴眼液治疗白内障术后角膜水肿的临床效果。方法 2014年1月—2016年1月选择在北京市顺义区妇幼保健院诊治的白内障术后角膜水肿患者78例,根据随机信封抽签原则分为观察组与对照组各39例,对照组给予玻璃酸钠滴眼液治疗,观察组给予贝复舒滴眼液联合玻璃酸钠滴眼液治疗,两组都连续治疗观察4周。比较两组临床疗效、治疗前后视力状况、并发症情况及炎症因子白细胞介素-6(IL-6)和肿瘤坏死因子-α(TNF-α)水平。结果治疗后观察组的有效率(98.7%)明显高于对照组(88.5%),差异有统计学意义(P<0.05)。治疗后观察组与对照组的视力明显好于治疗前,同组治疗前后比较差异有统计学意义(P<0.05);同时观察组治疗后的视力明显好于对照组,差异有统计学意义(P<0.05)。观察组治疗期间的新生血管性青光眼、瞳孔区模性渗出、玻璃体积血等并发症发生率为7.7%,对照组为9.0%,两组对比无明显差异。治疗后观察组的泪液IL-6和TNF-α含量明显低于治疗前,同组治疗前后比较差异有统计学意义(P<0.05);同时治疗后观察组的泪液IL-6和TNF-α含量明显低于对照组,差异有统计学意义(P<0.05)。结论贝复舒滴眼液联合玻璃酸钠滴眼液治疗白内障术后角膜水肿能抑制泪液中炎症因子的表达,具有很好的安全性,从而提高治疗疗效与改善视力。
Objective To observe the clinical efficacy of sodium hyaluronate drops combined with Bei Fu Shu drops in the treatment of corneal edema after cataract surgery.Methods From January 2014 to January 2016,78 patients with corneal edema after cataract surgery in our hospital for treatment were selected as the research object,all the patients were divided into observation group and control group with 39 cases in each group accorded to the random draw envelope principle.The control group was given sodium hyaluronate drops treatment,the observation group was given Bei Fu Shu drops based in the treatment of the control group,all the patients were treated for 4 weeks.Results After treatment,the effective rate of the observation group and the control group were 98.7% and 88.5% respectively,and the effective rate of the observation group was significantly higher than that of the control group（P〈0.05）.After treatment,the visual acuity of the observation group and the control group were significantly better than that before treatment（P〈0.05）,and the visual acuity in the observation group after treatment was better than that of the control group（P〈0.05）.The complication rate of neovascular glaucoma,pupillary zone effusion and vitreous hemorrhage in the observation group during treatment was 7.7%,so that was 9% in the control group.After treatment,the IL-6 and TNF-α contents of tear in the two groups were significantly lower than that before treatment（P〈0.05）,and the IL-6 and IL-6 and TNF-α contents of tear after treatment in the observation group was significantly lower than the control group（P〈0.05）.Conclusion Sodium hyaluronate drops combined with Bei Fu Shu drops in the treatment of corneal edema after cataract surgery can inhibit the expression of inflammatory factors in tears and has good safety,which can improve the therapeutic effect and improve the visual acuity.
作者
苏学刚
SU Xuegang(Ophthalmology Department, Beijing shunyi District Maternity and Child Health care Center/Beijing Children＇s Hospital Shunyi Women＇s Hospital, Beijing 101300, Chin)
出处
《药物评价研究》
CAS
2018年第2期275-278,共4页
Drug Evaluation Research
关键词
玻璃酸钠
贝复舒
白内障
角膜水肿
炎症因子
Sodium hyaluronate
Bei Fu Shu
cataract
corneal edema
inflammatory factors
