摘要
目的探讨麦角新碱联合缩宫素对临产后剖宫产术产后出血的治疗效果。方法回顾性地对临产后剖宫产术产后出血的产妇进行对照研究。将300例有产后出血倾向的产妇分为对照组和观察组,对照组(100例)常规给催产素,观察1组(100例)在催产素的基础上加用卡前列素氨丁三醇注射液,观察2组(100例)在催产素的基础上加用麦角新碱。记录胎儿娩出后0.5、1、2、24 h出血量、血压、心率的变化及药物不良反应。结果治疗后,观察1、2组产妇产后1、2、24 h出血量均少与对照组,差异均有统计学意义(P<0.05);观察2组产妇产后1、2、24 h出血量明显少于观察1组,差异均有统计学意义(P<0.05)。对照组和观察1、2组产后出血发生率分别为19%和6%、2%,观察1、2组明显低于对照组,差异有统计学意义(P<0.05);观察2组明显低于观察1组,差异有统计学意义(P<0.05)。观察2组不良反应发生率明显低于观察1组,差异有统计学意义(P<0.05)。结论麦角新碱联合缩宫素对临产后剖宫产术产后出血有显著效果。
Objective To investigate the methysergide in labor cesarean section postpartum hemorrhage treatment effect.MethodsA retrospective control study of parturient was after cesarean section maternal postpartum hemorrhage.300 patients with postpartum hemorrhage were divided into observation group A and control group B.Group A100 were to oxytocin,oxytocin in B1 observation group based on the use of hemabate in 100 cases B2 in the observation group,oxytocin plus 100 cases.Record the fetus after 30 min,1 h,2 h,change and drug adverse reactions,blood pressure and heart rate of bleeding 24 h.Results There were significant differences in the amount of 1 h,2 h and 24 h bleeding after delivery in the two groups of pregnant women（P〈0.05）.There were significant differences in the amount of postpartum 1 h,2 h and 24 h bleeding between the two groups of B1 and B2（P〈0.05）.There was a significant difference between the two groups.The incidence of postpartum hemorrhage in group A and group B was 19% vs 4%,and the incidence of postpartum hemorrhage in group B1 and B2 group was 6% vs 2%,respectively.There were significant differences in postpartum 2 h systolic blood pressure and diastolic blood pressure between group B1 and group B2（P〈0.05）.There was a statistically significant difference in gastrointestinal reaction between B1 group and B2 group（P〈0.05）.Conclusion Ergonovine has significant effect on cesarean section postpartum hemorrhage after labor.
作者
金萍
石少权
JIN Ping1, SHI Shaoquan2(1. The department of Obstetric, Zhuhai Maternity and Child Healthcare Hospital, Zhuhai 519000, China 2. The department of Obstetrics and Gynecology, the Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai 519000, Chin)
出处
《药物评价研究》
CAS
2018年第2期302-304,共3页
Drug Evaluation Research
关键词
麦角新碱
预防和治疗
产后出血
ergonovine
prevention and treatment
postpartum hemorrhage
