摘要
目的探讨固本咳喘胶囊联合二羟丙茶碱片治疗缓解期支气管哮喘临床疗效。方法选取2015年1月—2016年1月天门市第一人民医院收治的缓解期支气管哮喘患者92例纳入本研究,所有患者采用随机数字表法分为对照组和治疗组,每组各46例。对照组口服二羟丙茶碱片,1片/次,3次/d。治疗组在对照组基础上口服固本咳喘胶囊,3粒/次,3次/d。两组患者均连续治疗3个月。观察两组的临床疗效,比较两组的肺功能、血气指标和炎性因子。结果治疗后,对照组和治疗组的总有效率分别为73.9%、89.1%,两组比较差异有统计学意义(P<0.05)。治疗后,两组呼气流速峰值(PEF)、呼气峰流量变异率(PEFR)和一秒用力呼气容积(FEV1)均明显增高,同组治疗前后比较差异有统计学意义(P<0.05);且治疗组这些观察指标明显高于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,两组血氧分压(p O_2)、酸碱度(p H)值明显升高,二氧化碳分压(p CO_2)显著降低,同组治疗前后比较差异有统计学意义(P<0.05);且治疗组这些观察指标的改善程度明显优于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,两组超敏C反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)和白细胞介素-4(IL-4)水平均明显降低,同组治疗前后比较差异有统计学意义(P<0.05);且治疗组这些观察指标明显低于对照组,两组比较差异具有统计学意义(P<0.05)。结论固本咳喘胶囊联合二羟丙茶碱片治疗缓解期支气管哮喘具有较好的临床疗效,可改善患者肺功能,调节血气指标和炎性因子,具有一定的临床推广应用价值。
Objective To explore the clinical effect of Guben Kechuan Capsules combined with Diprophylline Tablets in treatment of remission stage of bronchial asthma. Methods Patients（92 cases） with remission stage of bronchial asthma in Tianmen First People＇s Hospital from January 2015 to January 2016 were randomly divided into control and treatment groups, and each group had 46 cases. Patients in the control group were po administered with Diprophylline Tablets, 1 tablet/time, three times daily. Patients in the treatment group were po administered with Guben Kechuan Capsules on the basis of the control group, 3 grains/time, three times daily. Patients in two groups were treated for 3 months. After treatment, the clinical efficacies were evaluated, and lung functions, blood gas indexes, inflammatory factors in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 73.9% and 89.1%, respectively, and there was difference between two groups（P〈0.05）. After treatment, PEF, PEFR, and FEV1 in two groups were significantly increased, and the difference was statistically significant in the same group（P〈0.05）. And the observational indexes in the treatment group were significantly higher than those in the control group, with significant difference between two groups（P〈0.05）. After treatment, p O2 and p H in two groups were significantly increased, but p CO2 in two groups were significantly decreased, and the difference was statistically significant in the same group（P〈0.05）. And the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups（P〈0.05）. After treatment, the levels of hs-CRP, TNF-α, and IL-4 in two groups were significantly decreased, and the difference was statistically significant in the same group（P〈0.05）. And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups（P〈0.05）. Conclusion Guben Kechuan Capsules combined with Diprophylline Tablets has clinical curative effect in treatment of remission stage of bronchial asthma, can improve lung function, regulate blood gas indexes and inflammatory factors, which has a certain clinical application value.
出处
《现代药物与临床》
CAS
2018年第2期295-298,共4页
Drugs & Clinic
关键词
固本咳喘胶囊
二羟丙茶碱片
缓解期支气管哮喘
肺功能
血气指标
炎性因子
Guben Kechuan Capsules
Diprophylline Tablets
remission stage of bronchial asthma
lung function
blood gas index
inflammatory factor
