摘要
抗肿瘤抗生素来源于微生物的代谢物及其衍生物,是一类重要的细胞毒类抗肿瘤药物,结构独特、活性优良,但具有明显的毒副作用也是其显著的特点。近年来不断有新的抗肿瘤抗生素被发现,按照不同的作用机制,分别对干扰肿瘤细胞DNA结构与功能,抑制肿瘤细胞分裂、增殖和迁移,抑制肿瘤细胞重要蛋白酶,诱导肿瘤细胞凋亡,通过自由基损伤发挥作用的抗肿瘤抗生素的研究进展进行综述,并展望其在未来临床中的应用。
Antitumor antibiotics, derived from microbial metabolites and their derivatives, are an important class of cytotoxic anfitumor drugs with unique structure and excellent activity, but their obvious toxic and side effects are also notable. New anticancer antibiotics have been found continuously in recent years. In this paper, antitumor antibiotics according to different mechanism of action such as interfering with the DNA structure and function of tumor cells, inhibiting tumor cell division, proliferation, and migration, inhibiting the important protease of tumor cells, inducing the apoptosis of tumor cell, acting through free radical damage are reviewed. And their future clinical applications are prospected.
出处
《现代药物与临床》
CAS
2018年第2期439-444,共6页
Drugs & Clinic
关键词
抗肿瘤
抗生素
作用机制
anticancer
antibiotics
antitumor
mechanism of action
