摘要
目的探讨标准化手术切除联合眼睑再造对眼睑基底细胞癌的治疗效果及对患者Ki67、Tmem16a和ILK的影响。方法将125例眼睑基底细胞癌患者根据不同治疗方式分为观察组与对照组。对照组患者接受标准化手术切除治疗,观察组患者在标准化手术切除基础上联合使用眼睑再造进行治疗。观察2组患者的治疗效果,并对患者手术前后Ki67、Tmem16a、ILK阳性率进行统计比较。结果治疗前,2组患者Ki67、Tmem16a和ILK指标阳性率无明显差异性(P>0.05);治疗后,观察组患者上述指标阳性率明显低于对照组(P<0.05)。观察组患者治疗有效率明显高于对照组(88.71%VS 65.08%,P<0.05),且观察组治疗满意度明显高于对照组(91.93%VS 68.25%,P<0.05)。结论标准化手术切除联合眼睑再造治疗眼睑基底细胞癌可以降低患者Ki67、Tmem16a和ILK阳性率,具有明显的治疗效果,疗效满意。
Objective To study the effect of standardized surgical resection combined with eyelid reconstruction for eye- lid basal cell carcinoma and its effect on Ki67,Tmem16a and ILK. Methods 125 patients with basal cell carcinoma of eyelid were divided into observation group and control group according to different treatment methods. The control group was treated with standardized surgical resection,while the observation group was used standardized surgical resection combined with eyelid recon- struction for treatment. The curative effects of 2 groups were observed, anti the positive rates of Ki67, Tmem16a and ILK before and after operation were statistically compared. Results Before treatment, there were no statistical significance about positive rate of Ki67,Tmem16a and ILK （P 〉 0.05）. After treatment, the positive rate of index stated above in the observation group were sig- nificantly lower than that in the control group （ P 〈 0.05 ） ; The elinical efficacy of the observation group was significantly higher than that of the control group （ 88.71% VS 65.08 %, P 〈 0.05 ）, with better treatment satisfaction （ 91.93 % VS 68.25 %, P 〈 0.05）. Conclusion Standardized surgical resection combined with eyelid reconstruction for eyelid basal cell carcinoma can re- duce positive rate of Ki67 ,Tmem16a and ILK,with obvious therapeutic effect and better satisfaction.
作者
古磊
GU Lei.(The First People＇s Hospital of Shuangliu District,Chengdu,61020)
出处
《实用癌症杂志》
2018年第4期537-540,共4页
The Practical Journal of Cancer
