摘要
[目的]探讨木粉尘职业暴露与肺癌的关系。[方法]检索中国期刊全文数据库(CNKI)、中国科技期刊全文数据库(VIP)、万方数据库、Pubmed、Science Direct、Wiley Online Library、Web of Science、Google Scholar等,主题词包括"木粉尘""木尘""硬木尘""软木尘""木屑""肺癌""肺肿瘤""wood dust""hardwood dust""softwood dust""saw dust""lung cancer""lung carcinoma""lung malignancy",按照入选和排除标准筛选文献,采用Stata 12.0软件,用I2统计量进行异质性检验,利用固定效应模型合并效应值,用Egger法检验发表性偏倚。[结果]共纳入17篇关于职业性接触木粉尘与肺癌关联的病例对照研究文献。木粉尘职业暴露与肺癌发生有关联,发生风险增高,未校正混杂因素的合并OR=1.61(95%CI:1.46~1.78),调整后合并OR=1.49(95%CI:1.33~1.65)。木粉尘职业暴露引起其他类型肺癌的发生风险最高OR=1.48(95%CI:1.19~1.84),其次为鳞癌[OR=1.43(95%CI:1.16~1.75)]和腺癌[OR=1.29(95%CI:1.06~1.57)]。漏斗图和Egger法均显示本研究可能不存在发表偏倚。[结论]木粉尘职业暴露可能增加肺癌发生风险。
[Objective] To assess the relationship between occupational exposure to wood dust and lung cancer.[Methods] Studies were identified through CNKI, VIP, Wanfang data, Pubmed, Science Direct, Wiley Online Library, Web of Science and Google Scholar, and the theme words included ＂wood dust, ＂ ＂hardwood dust, ＂ ＂softwood dust, ＂ ＂saw dust, ＂ ＂lung cancer, ＂ ＂lung carcinoma, ＂ and ＂lung malignancy, ＂ in both Chinese and English. Studies were included according to inclusion and exclusion criteria. Heterogeneity test, combined effect value, and publication bias were carried out with I 2 statistics, fixed effect model, and Egger test method using Stata 12.0 software respectively.[Results] Seventeen papers reporting occupational exposure to wood dust and lung cancer were included. An increased risk of lu ng cancer was associated with occupational exposure to wood dust （unadjusted OR=1.61, 95%CI：1.46-1.78; adjusted OR=1.49, 95%CI：1.33-1.65）. The highest risk of occupational exposure to wood dust was found in the category of other lung cancer （OR=1.48, 95%CI：1.19-1.84）, followed by squamous cell carcinoma （OR=1.43, 95%CI：1.16-1.75）, and adenocarcinoma （OR=1.29, 95%CI：1.06-1.57）. The Funnel plot and Egger test results showed no publication bias in this study.[Conclusion] Occupational exposure to wood dust might increase the risk of lung cancer.
作者
杨秋月
王海椒
YANG Qiu-yue, WANG Hai-jiao(National Research Center for Occupational Safety and Health, State Administration of Work Safety, Beijing 102308, Chin)
出处
《环境与职业医学》
CAS
CSCD
北大核心
2018年第3期266-271,共6页
Journal of Environmental and Occupational Medicine
基金
国家重点研发计划资助(编号:2016YFC0801700)
关键词
木粉尘
职业暴露
肺癌
META分析
病例对照研究
wood dust
occupational exposure
lung cancer
meta analysis
case-control study
