摘要
目的:观察自拟活血止痛合剂治疗小儿矫形术后疼痛的临床疗效。方法:将80例符合纳入标准的患儿按随机数字表法分为对照组和观察组,每组40例。对照组给予枸缘酸芬太尼注射液作术后镇痛治疗,观察组采用自拟活血止痛合剂(方药组成:香附子10 g,乳香10 g,川芎10 g,红花10 g,当归10 g,葛根10 g,丹参15 g,仙鹤草15 g,炒栀子10 g,血余炭10 g,甘草5 g,牡丹皮15 g,黄柏10 g,大黄10 g,三七5 g,枳壳10 g,桃仁10 g,没药10 g,赤芍20 g。用法:口服,每次30 mL,每天3次)作镇痛治疗。比较两组患者术后不同时间段疼痛的改善情况,及不良反应情况。结果:(1)术后4 h,观察组疼痛评分降低至(5.94±1.55)分,与本组术后2 h(7.06±1.85)分比较,差异有统计学意义(P<0.05);对照组则术后4 h上升至(9.01±2.02)分,与本组术后2 h比较,差异有统计学意义(P<0.05);术后4 h疼痛评分观察组与对照组比较,差异有统计学意义(P<0.05)。(2)观察组术后2 h,无痛、轻度、中度疼痛所占比例分别为20.00%、55.00%、25.00%,与对照组的30.00%、45.00%、25.00%比较,差异无统计学意义(P>0.05)。(3)观察组术后4 h,无痛患者所占比例为37.50%,明显高于对照组的12.50%,且观察组中度疼痛患者所占比例为2.50%,显著低于对照组的40.00%,两组无痛、中度疼痛比较,差异均有统计学意义(P<0.05)。(4)两组患者不良反应比较,差异无统计学意义(P>0.05)。结论:在小儿矫形术术后镇痛治疗中,采用自拟活血止痛合剂方,可改善患儿术后疼痛程度,提升镇痛效果。
Objective：To observe the improvement effect of self-designed Huoxue Zhitong mixture for pain after pediatric orthopedy.Methods：80 cases of children in accordance with the inclusion criteria were divided into the control group and the observation group according to the random number table method,with 40 cases in each group.The control group was only treated with citric acid fentanyl injection for postoperative analgesic treatment while the observation group was treated with self-designed Huoxue Zhitong mixture for analgesic intervention.The composition：Xiangfuzi（Rhizoma Cyperi） 10 g,Ruxiang（Frankincense） 10 g,Chuanxiong（Ligusticum Wallichii） 10 g,Honghua（Red Flower） 10 g,Danggui（Angelica Sinensis） 10 g,Gegen（Radix Puerariae） 10 g,Danshen（Salvia Miltiorrhiza） 15 g,Xianhecao（Herba Agrimoniae） 15 g,Chaozhizi（Fried Fructus Gardeniae） 10 g,Xueyutan（Carbonized Hair） 10 g,Gancao（Liquorice） 5 g,Mudanpi（Moutan Bark） 15 g,Huangbai（Cortex Phellodendri） 10 g,Daihuang（Rheum Officinale） 10 g,Sanqi（Panax Notoginseng） 5 g,Zhike（Fructus Aurantii） 10 g,Taoren（Peach Kernel） 10 g,Moyao（Myrrh） 10 g,Chishao（Radix Paeoniae Rubra） 20 g.Oral,30 mL each time,3 times a day.The pain improvement different time after operation and adverse reaction were compared between the two groups.Results：（1）4 h after operation,the pain score in the observation group decreased to（5.94±1.55） points.Compared with the points（7.06±1.85） that in the group 2 h after operation,the difference was statistically significant（P0.05）.In the control group,it increased to（9.01±2.02） points,compared with that in the group 2 h after operation,the difference was statistically significant（P0.05）.For the comparison between the two groups,the difference in pain score in 4 h after operation was statistically significant（P0.05）.（2）In the observation group,2 h after operation,the proportions of no pain,mild and moderate pain were 20.00%,55.00% and 25.00%.Compared with 30.00%,45.00% and25.00% in the control group,the differences were not statistically significant（P0.05）.（3）In the observation group,4 h after operation,the proportion of no pain was 37.50%,which was significantly higher than 12.50% in the control group.And the proportion of moderate pain in the observation group was 2.50% which was significantly lower than 40.00% in the control group.The differences in the proportions of no pain and moderate pain were statistically significant（P0.05）.（4）The difference in the incidence rate of analgesic adverse events between the two groups was not statistically significant（P0.05）.Conclusion：In the analgesic treatment for pediatric orthopedy,adopting self-designed Huoxue Zhitong mixture can improve the postoperative pain degree of children and enhance the analgesic effect.
作者
胡南
廖紫琼
HU Nan,LIAO Ziqiong(Xiangyang Hospital of Traditional Chinese Medicine,Xiangyang Hubei China 44100)
出处
《中医学报》
CAS
2018年第2期311-314,共4页
Acta Chinese Medicine
基金
湖北省自然科学基金资助项目(2008CBD088)
关键词
小儿矫形术
活血止痛合剂
枸缘酸芬太尼
镇痛
中医药治疗
中西医结合
pediatric orthopedy
Huoxue Zhitong mixture
fentanyl
analgesia
TCM therapy
combination of traditional Chinese and Western medicine
