摘要
目的探讨0～6个月的婴儿外周血血清免疫球蛋白IgG的变化规律，并比较分析母乳喂养与人工喂养对婴儿的免疫功能的影响。方法纳入2016年1—12月出生的新生儿90例，根据新生儿喂养方式分为母乳喂养组、混合喂养组和人工喂养组，每组30例。分别于出生后1d、3d、7d、14d、42d、3个月和6个月时采集外周血，对血清中IgG含量进行放射免疫分析测定，比较各组含量变化。并于婴儿出生后6个月检测外周血T淋巴细胞亚群（CD3＋、CD4＋、CD8＋）数量。结果新生儿血清IgG含量随出生后日龄增加而逐渐下降。婴儿出生后14d，母乳喂养组、混合喂养组和人工喂养组的血清IgG含量分别为（95．14±4．55）、（90．89±4．35）、（91．74±4．19）mg／L，母乳喂养组明显高于混合喂养组和人工喂养组，组间差异有统计学意义（F=7．965，P〈0．05）；且母乳喂养组、混合喂养组和人工喂养组CD8＋T淋巴细胞分别为0．3894±0．0601、0．2942±0．0626、0．3084±0．0716，母乳喂养组显著高于混合喂养组和人工喂养组，组间差异有统计学意义（F=4．941，P〈0．05）。结论母乳喂养可以有效降低婴幼儿血清IgG含量的消耗，减缓其下降速度，有效提高婴儿自身合成IgG能力，从而提高婴幼儿免疫力，促进其健康成长，值得临床推广应用。
Objective To investigate the changes of serum immunoglobulin IgG in peripheral blood of infants aged 0-6 months, and to compare the effects of breast feeding and artificial feeding on the immune function of infants. Methods A total of 90 neonates born from January 2016 to December 2016 were divided into three groups： breast feeding group, mixed feeding group and artificial feeding group. There were 30 newborns in each group. Peripheral blood samples were collected at postnatal 1 d, 3 d, 7 d, 14 d, 42 d, 3 months and 6 months respectively. Serum levels of IgG were determined by radioimmunoassay, and the contents of each group were compared. T lymphocyte subsets（CD3＋, CD4＋, CD8＋） in peripheral blood at postnatal 6 months were detected. Results The content of IgG in serum of neonatal decreased gradually with the increase of postnatal days. The serum IgG content at postnatal 14 d in the breast feeding group, the mixed feeding group and the artificial feeding group was （95.14±4.55）, （90.89±4.35）, （91.74±4.19） mg/L respectively, and the breast feeding group was significantly higher than the other two groups, the difference among the groups was statistically significant （F=7.965, P〈0.05）.The CD8＋ T lymphocyte cells in the breast feeding group, the mixed feeding group and the artificial feeding group was 0.389 4±0.060 1, 0.294 2±0.062 6, 0.308 4±0.071 6 respectively, and the breast feeding group was significantly higher than the mixed feeding group and the artificial feeding group, and the difference among the groups was statistically significant（F=4.941, P〈0.05）. Conclusions Breast feeding can reduce the serum IgG content of infant consumption, slowing the pace of decline, effectively improve the infant＇s own ability to synthesize IgG, so as to improve infant immunity, promote their healthy growth, it is worthy of clinical application.
作者
李瑞玲
李惠敏
游聚敏
Li Ruiling, Li Huimin, You Jumin(Department of Obstetrics and Gynecology, Shandong Heze City Hospital, Heze 274000, Chin)
出处
《中国实用护理杂志》
2018年第10期727-730,共4页
Chinese Journal of Practical Nursing
