摘要
目的通过雌激素及紫外线综合诱导出更接近黄褐斑的豚鼠黑色素模型,观察Q开关红宝石点阵激光+氨甲环酸外用对治疗色素沉着的有效性。方法自2015—2016年建立豚鼠色素沉着斑实验模型,并设定为未治疗组(A)、单纯外用氨甲环酸组(B)、单独Q开关红宝石点阵激光组(C)及Q开关红宝石点阵激光组+氨甲环酸外用组(D),分别采用不同治疗方法,治疗疗程为1个月;分别在治疗前和完成治疗后2、4周,采用拍照并肉眼评估、取材,进行黑色素细胞染色法和黑素颗粒染色法,观察表皮色素沉着、黑色素细胞数量、黑素颗粒表达的改变。结果通过各组黑素颗粒面积占表皮面积的百分比并统计黑色素细胞数量对比表明,低能量密度点阵QSRL可有效治疗色素沉着(P<0.05);B组与A组数据均无差异,对减退色素沉着无统计学意义(P>0.05);D组与C组比较,其差异无统计学意义(P>0.05)。结论本实验显示,Q开关红宝石点阵激光在治疗色素沉着斑实验模型方面有明显的效果,但氨甲环酸作为外用药物,无论是单用还是联合点阵QSRL(q switch ruby star laser)均未发挥明显作用,且联合治疗未能增加治疗疗效。
Objective To verify the clinical efficacy of Q-switched ruby laser combined with tranexamic acid in the treatment of pigmentation. Methods From 2015 to 2016 guinea pig pigmentation experimental models induced by estrogen and UVB were established, and were divided into four groups：（A） the untreated group,（B） the tranexamic acid for external use alone group,（C） the Q-switched ruby laser alone group and（D） the Q-switched ruby laser combined with tranexamic acid for external use. All groups received treatment for1 month. The epidermal pigmentation and quantity and melanocytes of pigment particles expressing change were observed before and after treatment at 2 and 4 weeks by photo visual assessment, melanocytic staining（Imokawa method）, and melanin granules staining（Masson-Fontana method）. Results Using the percentage of the area of melanin granules and the number of cells in each group, experimental results showed that low-energy density dot matrix QSRL was able to reduce the number of melanocytes, make the melanin particles smaller, and was effective in the treatment of pigmentation（P〈0.05）. The tranexamic acid injection for external use alone group was not significantly different from the untreated group, with no significant loss of pigment（P〈0.05）. No statistical significance differences existed between the combination therapy and dot matrix laser treatment alone（P〈0.05）. Conclusion Q-switched ruby laser has obvious efficacy in the treatment of chloasma. The study has shown that tranexamic acid as an external medicine, whether on its own or combined with lattice QSRL, does not play a significant role.
作者
李倩
曹莫
LI Qian;CAO Mo(Department of Plastic Surgery, Affiliated hospital of NCO Academy of Army medical university, Shijiazhuang 050041, China)
出处
《中国美容整形外科杂志》
CAS
2018年第3期141-144,152,共5页
Chinese Journal of Aesthetic and Plastic Surgery
