摘要
目的比较双相抑郁与首发抑郁症患者汉语成语N400成分的差异。方法纳入双相抑郁患者(BPD组)41例,首发抑郁症患者(FED组)43例,以及健康对照(HC组)40例,应用17项汉密尔顿抑郁量表(HAMD-17)及汉语成语N400进行检测。结果三组同音异形异义、形似异音异义、同义异音异形、异音异形异义的匹配和非匹配潜伏期比较差异均有统计学意义(P<0.05)。进一步两两比较显示,与HC组相比较,FED组所有4种类型的匹配和非匹配潜伏期均延长(P<0.05),BPD组同音异形异义的匹配和非匹配潜伏期延长(P<0.05);与FED组比较,BPD组异音异形异义的匹配和非匹配潜伏期均缩短(P<0.05)。三组同音异形异义、形似异音异义、同义异音异形、异音异形异义的匹配波幅比较差异均有统计学意义(P<0.05),三组同音异形异义的非匹配波幅比较差异有统计学意义(P<0.05)。进一步两两比较发现,BPD组与FED组和HC组分别比较,在同音异形异义、形似异音异义、同义异音异形的匹配波幅均增高(P<0.05);BPD组与FED组比较,异音异形异义的匹配波幅和同音异形异义的非匹配波幅均增高(P<0.05)。结论双相抑郁和首发抑郁症患者均存在语言功能异常。
Objective To explore the status of Chinese idiom-N400 in patients with bipolar depressive disorder and first- episode depressive disorder. Methods A total of 41 patients with bipolar depressive disorder in BPD group, 43 patients with first episode depressive disorder in FED group, 40 healthy people in control group were selected and assessed with 17-items Hamilton Depression Scale （ HAMD-17 ） and Chinese idiom-N400. Results There were significant differences for the congruent and incongruent latencies of all types of N400 between three groups （ P 〈 0.05 ）. The congruent and incongruent latencies of all types of N400 in FED group were significantly more than those in control group（ P 〈 0.05）. The congruent and incongruent latencies of ending words with same pronunciation but different forms and meanings in BPD group were significantly more than those in control group（P 〈0.05）. The congruent and incongruent latencies of ending words with different pronunciation, forms and meanings in BPD group were significantly less than those in FED group （ P 〈 0.05 ）. There were significant differences for the congruent latencies of all types and the incongruent amplitudes ofending words with different forms, meanings of N400 between three groups （P 〈 0.05）. The congruent amplitudes of ending words with same pronunciation but different forms and meanings, with similar forms but different pronunciation and meanings,with same meanings but different pronunciation and forms of N400 in BPD group and FED group were all significantly more than those in control group（P 〈 0.05 ）. The congruent amplitudes of ending words with different pronunciation, forms and meanings, the incongruent amplitudes of ending words with same pronunciation but different forms and meanings of N400 in BPD group were all significantly more than those in FED group（P 〈 0.05）. Conclusion There is abnormal for the function of language in the patients with bipolar depressive disorder and first-episode depressive disorder.
作者
王勇
赵雅娟
赵国庆
符浩
周儒白
王凡
毛睿智
杨涛
陈俊
黄佳
粟幼嵩
曹岚
陈兴时
方贻儒
WANG Yong, ZHAO Yajuan,ZHAO Guoqing, et al.(Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, CAS Center for Excellence in Brain Science and Intelligence Technology; Shanghai Key Laboratory of Psychotic disorders; Shanghai 200030, Chin)
出处
《精神医学杂志》
2017年第6期405-409,共5页
Journal of Psychiatry
基金
"十二五"国家科技支撑项目(编号:2012BAI01B04)
"十三五"国家重点研发计划资助项目"重大慢性非传染性疾病防控研究"(编号:2016YFC1307100
2016YFC1307102)
上海市精神疾病临床医学中心(编号:2014)
上海市卫生和计划生育委员会面上科研项目(编号:201640107)
上海交通大学"医工(理)交叉研究基金"(编号:YG2016MS39)
关键词
双相抑郁
首发抑郁症
汉语成语
N400
早期识别
Bipolar depressive disorder First episode depressive disorder Chinese idiom N400 Early identification
