摘要
SIRT1是Sirtuin基因家族成员之一,是一种具有烟酰胺腺嘌呤二核苷酸(NAD+)依赖性脱乙酰酶活性的组蛋白去乙酰化酶。帕金森病(PD)属于运动障碍性疾病,α-突触核蛋白的错误折叠、聚集及多巴胺能神经元的缺失是该病的重要病理改变。大量研究证实SIRT1通过去乙酰化组蛋白及众多转录因子,如p53、PGC-1α等,抵抗α-突触核蛋白的神经毒性,对PD产生神经保护作用。
SIRT1, a member of the Sirtuin family, is a histone deacetylase with nieotinarnide adenine dinucleo- tide （NAD＋） dependent deacetylase activity. Parkinson＇s disease is a type of movement disorders. The misfolding, aggre- gation of α-synuelein and the loss of dopaminergic neurons are important pathological changes in PD. A large number of studies confirmed that SIRT 1 display neuroprotective effects against α-synuclein neurotoxicity through deacetylating his- tone and numerous transcription factors including p53, PGC-1α, and others.
作者
陈晓婷
徐思敏
崔理立
陈煜森
CHEN Xiao-ting 1, XU Si-min 1, CUI Li-li 2, CHEN Yu-sen 1(1. Department of Neurology, Affiliated Hosptial of Guangdong Medical University, Zhanjiang 52400）, Guangdong, CHINA; 2. Guangdong Key Laboratory of Age-Related Cardiac and Cerebral Diseases, Zhanjiang 524000, Guangdong, CHINA)
出处
《海南医学》
CAS
2018年第6期815-817,共3页
Hainan Medical Journal
基金
国家自然科学基金青年基金(编号:81401061)
