摘要
目的探讨乙肝肝硬化患者治疗前后血浆D-二聚体(D-D)水平变化及其临床意义。方法选取2014年1月至2016年6月本院收治的112例乙肝肝硬化患者作为研究对象,其中肝功能Child-Pugh分级A级(21例)、B级(55例)、C级(36例),将上述研究对象随机分为对照组(56例)和观察组(56例),对照组接受肝硬化常规方案治疗,观察组在肝硬化常规方案治疗基础上再接受抗病毒治疗。采用免疫比浊法检测所有研究对象治疗前、治疗3、6、9个月后的血浆D-D浓度。结果治疗前,肝功能Child-Pugh分级A级、B级、C级患者血浆D-D水平比较差异有统计学意义(P<0.05),C级、B级患者血浆D-D水平显著高于A级,C级患者血浆D-D水平显著高于B级,差异均有统计学意义(P<0.05)。治疗前观察组和对照组血浆D-D水平比较差异无统计学意义(P>0.05),治疗3、6、9个月后,两组患者血浆D-D水平均逐渐降低,差异有统计学意义(P<0.05),观察组各时间点均显著低于对照组,差异均有统计学意义(P<0.05)。结论乙肝肝硬化患者血浆D-D水平与其肝功能状况密切相关,常规治疗、抗病毒治疗均可以降低乙肝肝硬化患者血浆D-D水平。
Objective To investigate the changes and clinical significance of plasma D-dimer （D-D） levels in patients with hepatitis B cirrhosis before and after treatment. Methods A total of 112 patients with hepatitis B cirrhosis in our hospital from January, 2014 to June, 2016 were selected as the subjects, including liver function classification, Child-Pugh grade A（21 cases）, grade B （55 cases） and grade C （36 cases）. The subjects were randomly divided into the control group （56 cases ） and the observation group （56 cases ）. The control group received routine treatment of liver cirrhosis, and the observation group received antiviral treatment on the basis of routine treatment of liver cirrhosis. Serum concentrations of D- D were measured before and after treatment for 3 months, 6 months and 9 months. Results There was statistical significant difference in plasma D-D levels of liver function Child-Pugh grade A, grade B and grade C before treatment （P〈0.05） ; plasma levels of D-D in grade B and C were significantly higher than that of grade A （P〈0.05） ; plasma level of D-D in grade C was significantly higher than that of grade B （P〈0.05）. There was no significant difference in level of plasma D-D between the observation group and control group before treatment （P〉0.05） ; plasma levels of D-D in the two groups after treatment for 3 months, 6 months and 9 months were significantly reduced gradually （P〈0.05） , and the D-D levels in the observation group at different time points were significantly lower than those of the control group （P〈0.05）. Conclusions Plasma D-D level was closely related to liver function in patients with hepatitis B cirrhosis. Conventional treatment and antiviral therapy could lower the plasma D-D level in patients with hepatitis B cirrhosis.
作者
张曼华
万延辉
张健杰
李培茂
李辉
熊煌
ZHANG Man-hua1, WAN Yan-hui2, ZHANG Jian-jie1, LI Pei-mao1, LI Hui1, XIONG Huang1(1.Guangdong Shenzhen Occupational Disease Prevention and Treatment Hospital, Shenzhen, Guangdong 518000; 2.Department of Thoracic Surgery, the Second People＇s Hospital of Shenzhen City （the First Affiliated Hospital of Shenzhen University）, Shenzhen, Guangdong 518000, China)
出处
《热带医学杂志》
CAS
2018年第3期377-379,共3页
Journal of Tropical Medicine
基金
深圳市科技计划项目(JCYJ20150403091305480)
