摘要
目的通过对丽水地区部分腹泻患儿粪便的轮状病毒(Rotavirus,RV)和腺病毒(Adenovirus,Adv)感染情况的分析,探讨本地区导致婴幼儿腹泻常见病原体的流行特征。方法收集2016年1月-2017年12月医院就诊的2951例腹泻患儿粪便,利用胶体免疫层析技术,快速诊断患儿粪便里的RV和Adv抗原,并对结果进行统计分析。结果腹泻患儿的粪便中,轮状病毒检出529例,感染率17.93%;腺病毒检出107例,感染率3.63%;轮状病毒和腺病毒双重感染55例,感染率1.86%;本地区轮状病毒感染的高发月份是11月至次年2月,以12月份最高,阳性率34.75%(P<0.001);腺病毒感染的高发月份是5月、6月,阳性率分别为22.32%、20.43%(P<0.001);轮状病毒和腺病毒双重感染的高发月份是12月至次年1月、阳性率分别为6.36%、4.20%(P<0.001),其中轮状病毒感染率随患儿年龄增加而下降(P<0.001),(6~12)月龄组患儿轮状病毒感染率最高。结论轮状病毒和腺病毒为本地区致儿童腹泻的主要病原体,并且发病具有明显的季节性,尤其要重视(0~12)月龄的婴幼儿腹泻感染轮状病毒和腺病毒的检查,选择快速准确的诊断方法,对于临床的诊治非常必要。
OBJECTIVE To investigate the prevalence of rotavirus（RV）and adenovirus（Adv）infections in stool specimens of children with diarrhea in Lishui and explore the epidemiological characteristics of the common pathogens in the children with diarrhea.METHODS The stool specimens were collected from 2951 children with diarrhea who were treated in the hospital from Jan 2016 to Dec 2017,the RV and Adv antigens in the stool specimens were rapidly detected by using colloidal immunochromatography technique,and the statistical analysis was performed.RESULTS The RV was detected positive in 529 children with diarrhea,with the infection rate 17.93%;the Adv was detected positive in 107 children,with the infection rate 3.63%.Totally 55 children had double infections of RV and Adv,with the infection rate 1.86%.The RV infection was highly prevalent from November to February of next year and was most prevalent in December,with the positive rate 34.75%（P0.001）.The Adv infection was highly prevalent in May and June,and the positive rates were 22.32%and 20.43%,respectively（P0.001）.The double infection of RV and Adv was highly prevalent from December to January of next year,the positive rates were 6.36% and 4.20%,respectively（P0.001）,the incidence of RV infection was decreased with the age（P0.001）and was the highest in the children aged between 6 and 12 months.CONCLUSIONRV and Adv are the predominant pathogens causing diarrhea in the children in the area,and the diarrhea is characterized by seasonal distribution.It is necessary to attach great importance to the detection of RV and Adv for the children with diarrhea aged between 0 and 12 months and choose the rapid and accurate diagnosis method so as to facilitate the clinical diagnosis and treatment.
作者
戴木根
刘思宇
丁文杰
叶斌
傅丽霞
DAI Mu-gen, LIU Si-yu, DING Wen-jie, YE Bin, FU Li-xia(Lishui Central Hospital, Lishui , Zhejiang 323000, Chin)
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2018年第6期936-938,952,共4页
Chinese Journal of Nosocomiology
基金
浙江省中医药基金资助项目(2015ZA226)
丽水市公益技术研究社会发展基金资助项目(2015CC33288)
