摘要
采用离体小白鼠皮肤为透皮屏障,用简单小室法,以生理盐水为接受液,研究了盐酸普萘洛尔在氮酮,薄荷油促进剂的作用下的透皮吸收效果,在1%盐酸普萘洛尔溶液中加入2%促吸剂,促进效果依次为氮酮、薄荷油。
The effect of transdermal penetration enhancers for the propranolo hydrochlor-ide in vitro from the aqueons solution througsh excised rat skin was studiedusing simple diffusion cells and normal saline as receptor. The results showedthat the 24h accumulative penetration amount and the penetration rate from 1%(w/v) solution containing 2%(w/v) of Azone was higher than that containing 2%(w/v) of peppermint oil.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
1991年第10期455-456,共2页
Chinese Journal of Hospital Pharmacy
关键词
盐酸心得安
氮酮
薄荷油
透皮吸收
Propranolol Hydrochloride
Azone
Peppermint oil
Transdermal Penetratin
