摘要
利用辐射接枝技术制得聚乳酸(消旋,PDLLA)接枝N-乙烯基吡咯烷酮(NVP)(PDLLA-g-NVP)材料,并通过静电纺丝制备改性纤维膜,并对PDLLA-g-NVP进行了测试。研究结果表明:10%接枝率的PDLLA-g-NVP在降解90d时,纤维表面呈蜂窝状,纤维出现断裂,具有较好的亲水性,膜纤维平均直径为1.270μm,失重率为41.2%,在临床医疗领域具有较好的应用前景。
Poly（lactic acid）grafting N-vinyl pyrrolidone（PDLLA-g-NVP）were prepared by gamma irradiation and electrospinning technology.The degradation behavior of PDLLA-g-NVP was studied in phosphate-buffered saline（PBS,pH 7 4±0 1）at 37℃.A series of analyses and characterizations（including morphologic changes,loss weight,DSC,FT-IR-ATR and 1 H-NMR）were conducted to the nanofibrous film after degradation and the results showed that the addition of NVP increased the degradation rate of PDLLA-g-NVP fiber film.SEM photos showed that the surface of grafting film with 10% and 15% grafting ratio were compact and no hole,and the fibers＇ surfaces appeared a large number of cellular structures and turned to break after 90 days degradation.The average diameter of fiber was1.270μm,and the mass lose was 41.2%.This method broaden the application fields of material and showed the promising in clinical areas.
作者
王静霞
陈屿恒
倪茂君
陈竹平
刘思阳
彭朝荣
Wang Jingxia ,Chen Yuheng, Ni Maojun, Chen Zhuping ,Liu Siyang, Peng Chaorong(Sichuan Institute of Atomic Energy,Chengdu 61010)
出处
《化工新型材料》
CAS
CSCD
北大核心
2018年第3期152-155,共4页
New Chemical Materials
基金
四川省应用基础项目(2015JY0135)
四川省科技支撑项目(2015SZ0089
2017SZ0101)
