摘要
目的:利用分子印迹技术制备左旋延胡索乙素(L-THP)微球。方法:以L-THP为模板分子,甲基丙烯酸(MAA)为功能单体,乙二醇二甲基丙烯酸酯(EDMA)为交联剂,使用沉淀聚合法制备L-THP微球,并考察该微球的吸附能力和在模拟胃液中的释药性能。结果:L-THP印迹微球能特异性地吸附L-THP,最大吸附量可达1.97μmol/g,分子印迹聚合物在模拟胃液中5 h内表现出明显的药物缓释能力。结论:L-THP印迹微球对L-THP具有良好的吸附能力和一定的缓释能力。
Objective： To prepare the sustained release microspheres of L-tetrahydropalmatine（ L-THP） by the molecular imprinting technique. Methods： L-THP was used as template,methyl acrylic acid（ MAA） was used as functional monmer,ehtylene glycol dimethacrylate（ EDMA） was used as a cross-linking agent to prepare the sustained release microspheres. L-THP microspheres was prepared by precipitation polymerization,and a test was conducted to investigate the performance of adsorption and drug controlled release in artificial gastric juice. Results： The experiment showed that the sustained release microspheres had specific adsorption to L-THP,the adsorption capacity was up to 1. 97 μmol/g,the molecular imprinted polymers（ MIPs） microspheres had obvious drug release capacity in artificial gastric juice in 5 h. Conclusion： The sustained release microspheres have a good adsorption and drug controlled release performance of L-THP.
作者
李博
朱俊访
聂阳
LI Bo1 ,ZHU Jun-fang1 ,NIE Yang2(1. Guangdong Food and Drug Vocational College, Guangzhou 510520, China; 2. Traditional Chinese Medical Institute of Guangdong Province, Guangzhou 510520, Chin)
出处
《中药材》
CAS
北大核心
2017年第9期2138-2140,共3页
Journal of Chinese Medicinal Materials
基金
广东省医学科学技术研究基金项目(A2015470)
广东省中医药局科研项目(20162027)
关键词
分子印迹技术
微球
左旋延胡索乙素
分子印迹聚合物
Molecular imprinting technique
Microspheres
L-tetrahydropalmatine
Molecular imprinted polymers
