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高效液相色谱法测定人血浆中舒乐安定的浓度 被引量:6

Determination of estazolam concentration in human plasma by HPLC
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摘要 本文应用高效液相色谱法测定人血浆中舒乐安定的浓度。检测波长为240nm,利眠宁为内标,甲醇:磷酸盐缓冲液为移动相。回收率为97.3~108.9%,日内和日间误差(浓度0.60μg/ml)(CV)分别为2.5%和2.9%(n=9)。对临床数十名患者血浓测定,其血浓在0.4~0.87μg/ml,为临床合理用药提供了依据。 Estazolam concentration in human plasma was determined by reverve phase HPLCwith UV detector at 240 nm.Chlordiazepoxide was used for internal standard. Therecorvery was 97.3~108.9%, the within day and day-to-day CV was 2.5% and 2.9%(n=9) at concentration range of 0. 15~0.60μg/ml, respectively. The method was sensitive to 0.05μg/ml plasma. The estazolam levels in 10 pateints were analyzedby this method. The plasma drug levels were at 0.40~0.87μg/ml. The result prov-ided a scientific basis for Clinical therapy.
出处 《中国医院药学杂志》 CAS CSCD 北大核心 1991年第11期488-490,共3页 Chinese Journal of Hospital Pharmacy
关键词 舒乐安定 血药浓度 HPLC estazolam plasma drug level HPLC
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