摘要
目的：探讨丙戊酸钠血药浓度与其抗癫痫疗效的相关性，并分析不良反应发生情况。方法：回顾性分析深圳市宝安区中心医院2014年1月~2017年9月诊治的60例癫痫患者的临床资料，均为单用丙戊酸钠治疗并监测其血药浓度，观察其临床疗效和不良反应发生情况。结果：丙戊酸钠血药浓度≥50mg／L且〈100mg／L时为有效血药浓度，治疗总有效率为78％，与血药浓度〈50mg／L组的总有效率57％（χ^2=7．589，P=0．001）和血药浓度≥100mg／L组的总有效率67％（χ^2=3．652，P=0．011）比较差异分别具有统计学意义（P〈0．05）。丙戊酸钠血药浓度≥50mg／L且〈100mg／L时不良反应发生率为9％，与血药浓度〈50mg／L组的7％比较，差异无统计学意义（χ^2=0，510，P=0．614），与血药浓度≥100mg／L组的33％比较，差异有统计学意义（χ^2=11．138，P=0．000）。结论：丙戊酸钠血药浓度在有效范围内疗效显著，且不良反应发生情况较少，安全性高，丙戊酸钠血药浓度和不良反应发生率呈正相关关系，因此在治疗过程中应密切监测血药浓度。
Objective： To investigate the correlation between serum concentration of sodium valproate and anti-epileptic efficacy, and to analyze the incidence of adverse reactions. Methods： Retrospective analysis was made about clinical data of 60 patients with epilepsy in our hospital from January 2014 to September 2017 in the diagnosis and treatment, who received the therapy with sodium valproate alone. The statistical plasma concentration of sodium valproate, clinical efficacy and incidence of adverse reactions were detected and correlatively analyzed. Results：The effective plasma concentration of sodium valproate was ≥50 mg/L and 〈100 mg/L,and the total curative rate was 78% ; the total effective rate of the group whose plasma concentration M50 mg/L was 57% （χ^2 ： 7. 589, P= 0. 001）and the total effective rate of the group whose plasma concentration 〉 100 mg/L was 67% （χ^2= 3. 652, P= 0. 011）. Their difference was statistically significant respectively（P〈0.05）. As the plasma concentration of sodium valproate was ≥50 mg/L and 〈100 mg/L,the incidence of adverse reaction was 9%,and there was no significant difference, compared with the incidence of 7 % in the 〈50 mg/L group（ χ^2= 0. 510, P = 0.614）, while there existed significant difference compared with the incidence of 33% in the 100 mg/L group（χ^2 = 11. 138, P = 0. 000）. Conclusion： The plasma concentration of sodium valproate has significant effect within the effective range, less adverse reactions and high safety, and there was positive correlation between plasma concentration of sodium valproate and the incidence of adverse reactions, therefore plasma concentration should be strictly monitored, in the course of treatment.
作者
王金莉
陈杰明
彭婷婷
林合麟
WANG Jinli,CHEN Jieming, PENG Tingting, et al(Department of Intensive Care Unit, Baoan Central Hospital of Shenzhen , Shenzhen （ 518000） ; Guangdong , China)
出处
《癫痫与神经电生理学杂志》
2018年第2期78-80,共3页
Journal of Epileptology and Electroneurophysiology(China)
关键词
丙戊酸钠
癫痫
血药浓度
不良反应
sodium valproate
epilepsy
plasma concentration
adverse reaction
