摘要
目的分析对急性胰腺炎疾病患者进行血清降钙素原（PCT）、肿瘤坏死因子-α（TNF-α）及白细胞介素-8（IL-8）动态监测的临床应用价值。方法选取急性胰腺炎患者60例，根据患者病情程度将23例轻症急性胰腺炎患者设为观察组1，37例重症急性胰腺炎患者设为观察组2，将观察组2患者中30例合并感染者设为观察亚组3，7例无合并感染者设为观察亚组4。于入院第1、3、7天检测所有患者血清PCT、TNF-α、IL-8水平，归纳分析上述指标动态监测对急性胰腺炎的临床诊断价值。结果观察组2不同时间段PCT、TNF-α和LI-8指标均高于观察组1，差异有统计学意义（P〈0.05）；观察组2中观察亚组3不同时间段血清PCT、TNF-α和LI-8指标均高于观察亚组4，但仅两亚组PCT水平比较差异有统计学意义（P〈0.05）。结论TNF-α和IL-8有助于判定急性胰腺炎患者病情发展程度，PCT则对于鉴别是否合并感染有突出价值，三种指标动态监测具有简便、准确性高等优势，值得临床推广。
Objective To investigate the clinical application value of dynamic monitoring of serum procalcitonin （PCT）, tumor necrosis factor-α （TNF-α） and interleukin-8 （IL-8） in patients with acute pancreatitis.Methods Sixty patients with acute pancreatitis were selected as subjects; according to the severity of disease, 23 cases of mild acute pancreatitis were divided into observation group 1 and 37 cases of severe acute pancreatitis were divided into observation group 2; of the patients in observation group 2, according to whether was complicated by infection, 30 infected patients were divided into observation subgroup 3, and 7 non-infected patients were divided into observation subgroup 4. The levels of serum PCT, TNF-α, IL-8 were detected at the 1st, 2nd and 7th day after admission; the clinical value of the dynamic monitoring of the above indexes in the diagnosis of acute pancreatitis was summarized and analyzed.Results Compared with observation group 1, levels of PCT, TNF-α and IL-8 were higher in observation group 2 in every detection phase, the difference was significant （P〈0.05）; the levels of PCT, TNF-α and IL-8 in observation subgroup 3 were higher than those in observation subgroup 4 in every detection phase, however only the difference in PCT levels between the two groups was statistically significant （P〈0.05）.Conclusions TNF-α and IL-8 are helpful in determining the intensity of acute pancreatitis and PCT has significance in identifying infection condition of patients; dynamic monitoring of the three indexes has advantages of simple, convenience and high accuracy, which is worthy of clinical promotion.
作者
张茹
秦刚
张书芬
Zhang Ru, Qin Gang, Zhang Shufen(Department of Laboratory, Heft Hospital Affiliated to Changzhi Medical College, Changzhi 046000, Chin)
出处
《中国实用医刊》
2018年第5期48-50,共3页
Chinese Journal of Practical Medicine
