摘要
类风湿关节炎（RA）是一种以侵蚀性关节炎为主要临床表现的自身免疫病，可发生于任何年龄。RA的发病机制目前尚不明确，基本病理表现为滑膜炎、血管翳形成，并逐渐出现关节软骨和骨破坏，最终导致关节畸形和功能丧失，可并发肺部疾病、心血管疾病、恶性肿瘤及抑郁症等。
To develop a new evidence-based diagnosis, treatment guideline for rheumatoid arthritis （RA） in China.A multidisciplinary guideline development group was established. The grading of recommendations assessment, development and evaluation （GRADE） system was used to rate the quality of evidence and the strength of recommendations. Recommendations were derived from evidence body, the balance of benefits and harmsand patient＇s values and preferences.The guideline development group developed 10 recommendations for the diagnosis and treatment of RA. The guideline covered the classification criteria, disease activity monitoring and assessing, antirheumatic drugs （DMARDs） and glucocorticoids with treat-to-target approach of RA.This rheumatoid arthritis guideline was intended to serve as a tool for clinicians and patients for best decisions-making in China.
出处
《中华内科杂志》
CAS
CSCD
北大核心
2018年第4期242-251,共10页
Chinese Journal of Internal Medicine
基金
国家重点研发计划精准医学研究重点专项（2017YFC0907605）
