摘要
目的探讨唐氏血清学指标与子宫动脉血流情况的相关性及对不良妊娠结局的预测价值。方法选取建档进行规范化产检的孕妇400例,唐氏血清学筛查指标异常的200例孕妇为实验组,其中神经管缺陷筛查(NTD)高风险者88例,NTD低风险组者112例。唐氏血清学指标正常的200例孕妇为对照组。实验组及对照组孕妇均测量其子宫动脉血流情况(PI、RI、S/D),并记录不良妊娠结局的发生情况,分析唐氏血清学指标与子宫动脉血流情况的相关性及对不良妊娠结局的预测价值。结果实验组中NTD高风险、低风险孕妇及对照组孕妇PI、RI、S/D值比较,差异有统计学意义(P<0.05)。实验组中NTD高风险、低风险孕妇及对照组孕妇不良妊娠结局发生率分别为17.05%(15/88)、8.93%(10/112)、2.00%(4/200),实验组与对照组比较,差异有统计学意义(P<0.05)。结论唐氏血清学筛查指标与子宫动脉血流相关,唐氏筛查风险越高,子宫动脉血流阻力越大,不良妊娠结局的发生率也越高。应给予唐氏血清学筛查指标异常的孕妇早期干预以改善子宫动脉血流,降低不良妊娠结局发生率。
Objective To investigate the correlation between Down＇s serological indexes and uterine arterial bloodstream and its predictive value for adverse pregnancy outcomes. Methods A total of 400 cases of pregnant women who underwent standardized quarantine were enrolled in this study.Among them,200 cases with abnormal serological screening indexes of Down＇s syndrome were selectedas the experimental group,and 200 cases with normal Down＇s serological index were selected as the control group. Pregnant women in the experimental group were divided into high-risk group（ 88 cases） and low-risk group（ 112 cases） according to Down＇s screening results. The uterine artery blood flow（ PI,RI,S/D） of the pregnant women in the experimental group and the control group were measured,and the adverse pregnancy outcomes were recorded,the correlation between Down＇s serological indexes and uterine artery bloodstream and its predictive value for adverse pregnancy outcomes were investigated.Results There were significant differences in average PI,RI and S/D values of high-risk group,lowrisk group and control group（ P〈0. 05）. The incidence of adverse pregnancy outcomes in high-risk group,low-risk group and control group respectively were 17. 05%（ 15/88）,8. 93%（ 10/112） and2. 00%（ 4/200）,there were significant differences between the experimental group and the control group（ P〈0. 05）. Conclusions Down＇s serological indexes are correlated with the uterine artery bloodstream. The lower the risk of Down＇s screening is,the greater the uterine artery blood flow resistance,and the higher the incidence of adverse pregnancy outcomes. The early intervention should be given to the pregnant women with abnormal serological screening index of Down＇s syndrome to improve uterine artery bloodstream and reduce the incidence of adverse pregnancy outcomes.
作者
陈杰英
黎璐珊
Chen Jieying;Li Lushan(Foshan Sanshui Maternal and Child Health Care Hospital, Foshan 528100, China)
出处
《临床医学》
CAS
2018年第3期20-22,共3页
Clinical Medicine
基金
佛山市医学类科技攻关项目(2015AB001305)~~
关键词
唐氏筛查
子宫动脉血流
不良妊娠结局
Down＇ s screening
Uterine artery bloodstream
Adverse pregnancy outcomes
