摘要
白杨素是一种具有多种药理活性的黄酮类化合物,但因其溶解性差及在肠道内易发生Ⅱ相代谢,从而导致其吸收差,生物利用度较低,这极大地限制了白杨素的临床应用。本文以"白杨素"、"黄酮"、"吸收"、"制剂"、"Chrysin"、"Flavonoids"、"Absorb"、"Preparation"等为关键词,组合查询1999~2017年在Pub Med、中国知网、万方、维普等数据库中的相关文献,对近年来白杨素制剂方面的研究进行综述,旨在为提高白杨素生物利用度和药效,促进其新制剂开发和临床应用提供参考。
Chrysin is a flavonoid compound with a variety of pharmacological activities. However, due to the poor solubility and prone to phase Ⅱ metabolism in intestine resulting in poor absorption and low bioavailability, the clinical application of chrysin is greatly limited. The article applied ahrysin, flavonoids, absorbption and preparation as the keywords, the related literatures from 1999 to 2017 on Pubmed, CNKI, ChianInfo, Wanfang and VIP were looked up, and the researches on chrysin preparations in recent years were summarized in order to provide reference for improving the bioavailability and pharmacodynamics of chrysin, and promote its new development and clinical application.
作者
屈勇
张怡
熊腾
黎娟
郑国华
Qu Yong;Zhang Yi;Xiong Teng;Li Juan;Zheng Guohua(Pharmacy Faculty, Hubei University of Chinese Medicine, Wuhan 430065, China;CR＆WISCO General Hospital)
出处
《中国药师》
CAS
2018年第4期714-717,共4页
China Pharmacist
关键词
白杨素
黄酮
吸收
制剂
生物利用度
药效
Chrysin
Flavonoids
Absorption
Preparation
Bioavailability
Pharmacodynamics
