摘要
目的:探讨益气通络方治疗糖尿病肾病(DKD)蛋白尿的临床疗效及可能的作用机制。方法:将80例2型DKDⅡ~Ⅲ期患者随机分成治疗组40例和对照组40例。对照组控制饮食、血糖、血脂、血压及使用血管紧张素转化酶抑制剂(ACEI)/血管紧张素Ⅱ受体拮抗剂(ARB)。治疗组在对照组基础上联用益气通络方,疗程3个月,观察临床症状、生化指标及ET-1和s TM等。结果:治疗组与对照组的临床总有效率经比较差异有统计学意义(P<0.05),经治疗后两组患者血糖、血脂均有下降;两组患者的尿蛋白量、ET-1、s TM含量均显著下降(P<0.05),且治疗组尿蛋白量、ET-1、s TM含量降低均优于对照组(P<0.05);两组患者治疗期间均未见明显副作用。结论:益气通络方治疗DKD可能是通过保护血管内皮功能,从而有效减少尿蛋白量,延缓DKD进展。
Objective： To explore the clinical effect and possible mechanism of Yiqi Tongluo Decoction on proteinuria of dia- betic kidney disease （DKD）. Methods：A total of 80 subjects with Phase Ⅱ-Ⅲ DN were randomly divide into control group and treatment group with 40 cases in each. The control group patients were under treament of the control of diet, blood pressure, serum glucose and lipid as well as conventional therapy, the treatment group patients were received the Yiqitongluo decoction on the basis of the therapy of the control group. The patients were followed up for 1 year. Results： The effective rates of the treatment group and the control group were 85% and 47.5% respectively. The effective rate between the two groups was significant different （ P 〈 0.05 ）. Serum glucose and lipid were significantly decreased two groups at the end of the follow - up. The urine protein , ET - 1 and sTM content from the treatment group were significantly reduced （ P 〈 0.05 ）, ET - 1 and sTM content in the treatment group was significantly reduced compared with the control group（P 〈 0.05 ）. Conclusion：The Yiqitongluo decoction may protect vascular endothelial function and significantly reduce urinary proteinuria and serum lipid to delay the progress of DKD which was superior to conventional therapy.
作者
徐贵华
袁利
陈永华
李雁
谢平
赵晋媛
汪年松
XU Guihua;YUAN Li;CHEN Yonghua;et al(Nephrology Department, Shanghai People＇ s 8th Hospital, Shanghai ,20023)
出处
《中国中西医结合肾病杂志》
2017年第10期866-868,共3页
Chinese Journal of Integrated Traditional and Western Nephrology
基金
上海市卫计委中医药科研基金资助项目(No.2010L096A)
上海市卫计委科研课题项目(No.20134079)
关键词
糖尿病肾病
益气通络方
蛋白尿
Diabetic kidney disease Yiqitongluo medicine Proteinuria
