摘要
卵巢癌是致命的妇科癌症之一。虽然目前的治疗策略相对有效,但存在易复发及化疗耐药,其与卵巢癌干细胞有着密切的联系。肿瘤干细胞(CSC)是肿瘤内罕见的化疗耐药性细胞,其可以用更多分化的子细胞填充大部分肿瘤,并可能导致复发性疾病。目前,对卵巢癌干细胞的分离与鉴定已经开展了很多研究,并分析了卵巢癌干细胞特异性标记物的特性。本文旨在对卵巢癌干细胞标记物的相关研究以及其作为治疗靶点的潜力进行综述。
Ovarian cancer is one of the fatal gynecological diseases.Although current therapeutic strategy is relatively effective,it is easy to relapse and there is chemotherapy resistance.Both of them are closely related to ovarian cancer stem cells.Tumor stem cells are rare chemotherapeutic resistant cells in tumor which can fill most of the tumors with its differentiated daughter cells and therefore cause recurrent disease.At present,there are many researches focusing on isolation and identification of ovarian cancer stem cells and analyzing the characteristics of ovarian cancer stem cell-specific markers.The aim of this paper is to make a review of related studies of ovarian cancer stem cell markers and its potential as therapeutic targets.
作者
于斯雯
韩世愈
Yu Siwen;Han Shiyu(Fourth Affiliated Hospital of Harbin Medical University ,Heilongjiang Harbin 150000, China.)
出处
《现代肿瘤医学》
CAS
2018年第10期1626-1629,共4页
Journal of Modern Oncology
基金
哈尔滨科技创新人才研究专项资金(编号:2016RAXYJ056)
关键词
卵巢癌
CSC
干细胞标记物
ovarian cancer, cancer stem cells, stem cell markers
