摘要
目的了解2014~2017年我国临床实验室血红蛋白A_2(HbA_2)和血红蛋白F(HbF)检测室内质控情况。方法收集2014~2017年参加卫生部临床检验中心室间质评参评单位回报的室内质控信息,将变异系数与1/3TEa(6.67%)和1/4TEa(5%)标准进行比较,得到满足各标准实验室的比例,进而分析我国HbA_2和HbF检测的室内质控情况。按照实验室使用的仪器不同进行分组,分别计算2017年HbA_2和HbF不同仪器组在两种标准下的变异系数通过率。结果HbA_2项目84%以上的实验室精密度都能达到1/3TEa的标准,达到1/4TEa标准的实验室比例略有降低(70.83%~84.47%)。HbF项目的结果除2015年外,当月和累积在控变异系数80%以上的实验室能达到1/3TEa标准,达到1/4TEa标准的实验室比例分布在68.42%~85.07%。2017年数据按仪器分组统计中,两个项目sebia capillarys 2仪器组和全自动血红蛋白分析仪伯乐VariantⅡ仪器组在两种标准下的变异系数通过率均达85%以上,精密度较好。结论目前我国实验室HbA_2和HbF检测的不精密度水平需进一步提高,尤其是HbF,实验室应继续加强室内质量控制,建立严格的室内质控制度,提高检测水平。
Objective To investigate the internal quality control（IQC）of hemoglobin A2（HbA2）and hemoglobin F（HbF）from 2014 to 2017 in China.Methods The results of IQC were collected from the laboratories which participated in external quality assessment（EQA）of National Center for Clinical Laboratories（NCCL）from 2014 to 2017,then the coefficient of variation（CV）was compared with 1/3 TEa（6.67%）,1/4 TEa（5%）.The proportion of laboratories meeting criteria were calculated to analyze IQC of HbA2 and HbF in China.The data were grouped based on the instruments used in laboratories,the acceptable rates of CVs of HbA2 and HbF in each group under two criteria in 2017 were calculated,respectively.Results In HbA2,more than 84% of participant laboratories met 1/3 TEa criteria and 70.83% ~84.47% of laboratories met 1/4 TEa criteria.In HbF except for 2015,the more than 80%laboratories whose month and cumulative CVs met 1/3 TEa and1/4 TEa criteria accounted for 68.42%~85.07%,respectively.Under 1/3 TEa and 1/4 TEa criteria,sebia capillarys 2 instrument and fully automatic hemoglobin analyzer bole VariantⅡ instrument group the acceptable rates of CVs above 85%,showed good precision for HbA2 and HbF detection.Conclusion At present,the precision level of HbA2 and HbF need to be further improved in laboratories of China,especially HbF.Laboratory should continue to strengthen the internal quality control,establish strict internal quality system to improve detection capacity.
作者
张志新
王薇
何法霖
钟堃
袁帅
刘佳丽
杜雨轩
王治国
ZHANG Zhi-xin;WANG Wei;HE Fa-lin;ZHONG Kun;YUAN Shuai;LIU Jia-li;DU Yu-xuan;WANG Zhi-guo(Beijing Hospital ,National Center of Gerontology,National Center for Clinical Laboratories/Beijing Engineering Research Center of Laboratory Medicine ,Beijing 100730 ,China)
出处
《现代检验医学杂志》
CAS
2018年第2期143-145,共3页
Journal of Modern Laboratory Medicine
