摘要
目的:研究中医辨证治疗下冠心病慢性心力衰竭中医证候微观量化指标生长转化因子-15(Growth Differentiation Factor 15,GDF-15)、转化生长因子-β1(Transforming Growth Factor-β1,TGF-β1)的临床意义。方法:便利抽取2014年10月~2016年10月在我院心内科诊治的冠心病患者80例,并根据患者诊断结果不同,将诊断为CHF的患者分为试验组68例,诊断为非CHF的患者分为对照组12例。对CHF试验组患者进行中医辨证,将其分为心肺气虚证组(记为A组)11例,气阴两虚证组(记为B组)22例,气虚血淤证组(记为C组)21例,阳虚水泛证组(记为D组)14例。在试验过程中,分别测定所有研究对象的血浆GDF-15、TGF-β1及NT-pro BNP水平,以对比分析中医辨证治疗下冠心病慢性心力衰竭中医证候与上述指标之间的关系。结果:试验组与对照组对比结果:试验组患者血浆GDF-15与NT-pro BNP水平远远高于对照组,差异具有统计学意义(P<0.05);试验组患者血浆TGF-β1水平远远低于对照组,差异具有统计学意义(P<0.05)。中医证候组与对照组患者对比结果:首先,各组之间血浆GDF-15水平、TGF-β1水平与NT-pro BNP水平总体分布差异明显;其次,中医证候组与对照组患者血浆GDF-15水平升序排列依次为:对照组、A组、B组、C组与D组;各组患者血浆TGF-β1水平升序排列依次为:D组、C组、A组、B组与对照组;各组患者血浆NT-pro BNP水平升序排列依次为:对照组、A组、B组、C组与D组。结论:血浆GDF-15与TGF-β1与冠心病慢性心力衰竭疾病密切相关;中医证候组与对照组患者血浆GDF-15水平升序排列依次为:对照组、A组、B组、C组与D组;各组患者血浆TGF-β1水平升序排列依次为:D组、C组、A组、B组与对照组。
Objective： To study the clinical significance of microscopic quantitative index of TCM syndrome Growth Differentiation Factor 15 and Transforming Growth Factor-β1 of chronic heart failure in coronary heart disease patients under traditional Chinese medicine under the treatment of syndrome differentiation. Methods： A total of 80 persons who met the inclusion criteria were selected from October 2014 to October 2016,and were divided into experimental group which were diagnosed as chronic heart failure（ n = 68）,and the controlled group which were not diagnosed as chronic heart failure（ n = 12）. The patients in CHF group were divided into cardiopulmonary syndrome group as A group（ n = 11）,pneumoconiosis group as B group（ n = 22）,angina pectoris group as C group（ n = 21） and Yang deficiency syndrome group as D group（ n = 14）. In the course of the experiment,in order to compare the clinical significance of the above indexes in patients with chronic heart failure undergoing coronary heart disease treated by TCM syndrome differentiation,plasma levels of GDF-15,TGF-β1 and NT-pro BNP were measured in all subjects. Results： Comparison between the experimental group and the controlled group： The levels of plasma GDF-15 and NT-pro BNP in the experimental group were significantly higher than those in the controlled group（ P0. 05）. The level of plasma TGF-β1 in the experimental group was significantly lower than that in the controlled group（ P 0. 05）. Comparison between the TCM syndromes and the controlled group： Firstly,the levels of plasma GDF-15,TGF-β1 and NT-pro BNP were significantly different between groups; Plasma GDF-15 levels were found in TCM syndromes and controlled by ascending order： The controlled group,the A group,the B group,the C group and the D group; Plasma TGF-β1 levels were found in TCM syndromes and controlled by ascending order： The D group,the C group,the A group,the B group and the controlled group; Plasma NT-pro BNP levels were found in TCM syndromes and controlled by ascending order： The controlled group,the A group,the B group,the C group and the D group. Conclusion： Plasma GDF-15 and plasma TGF-β1 are closely related to chronic heart failure in patients with coronary heart disease. Plasma GDF-15 levels were found in TCM syndromes and controls by ascending order：The controlled group,the A group,the B group,the C group and the D group; Plasma TGF-β1 levels are found in TCM syndromes and controls by ascending order： The D group,the C group,the A group,the B group and the controlled group.
作者
马强
张晶
MA Qiang;ZHANG Jing(Department of Traditional Chinese Medicine, Traditional Chinese Medicine Hospital of Yan＇an City Yanan Shaanxi 716000, China)
出处
《四川中医》
2018年第3期78-81,共4页
Journal of Sichuan of Traditional Chinese Medicine
关键词
冠心病慢性心力衰竭
GDF-15
TGF-Β1
中医辨证治疗
Chronic heart failure of coronary heart disease
Growth differentiation factor 15
Transforming growth factor-61
TCM syndrome differentiation
