摘要
目的探讨手足口病治疗中,热毒宁注射液的临床治疗效果。方法以该院2016年1—12月接诊的62例手足口病患儿为对象,按照随机数字排列法将其分为两组,对照组31例,给予利巴韦林,观察组31例,给予利巴韦林联合热毒宁治疗。观察两组患儿血常规变化、退热时间、症状消失时间、并发症发生率、病死率与危重症转化率、安全性。结果观察组WBC水平(56.21±19.20)×109/L明显高于对照组WBC水平(32.61±18.27)×109/L(t=4.958,P=0.028);观察组N水平(35.24±13.91)%明显高于对照组N水平(24.36±11.54)%(t=3.352,P=0.031);观察组退热时间(40.25±1.44)h明显低于对照组退热时间(52.54±1.74)h(t=30.267,P=0.002);观察组疱疹/皮疹消失时间(6.01±0.3)h明显低于对照组疱疹/皮疹消失时间(7.38±0.5)h(t=13.082,P=0.014);观察组转化为危重症发生率为6.25%,对照组转化为危重症发生率为13.33%(t=2.093,P=0.041)。结论在手足口病治疗中,热毒宁注射液可有效调节血常规中指标,促进临床症状改善,利于广大患儿恢复健康。
Objective To study the clinical curative effect of reduning injection in treatment of hand-foot-and-mouth diseases. Methods 62 cases of children with hand-foot-and-mouth diseases diagnosed in our hospital from January2016 to December 2016 were selected as the research objects and randomly divided into two groups with 31 cases in each, the control group were treated with ribavirin, while the observation group were treated with ribavirin combined with reduning, and the changes of blood routine test, defervescence time, disappearance time of symptoms, incidence rate of complications, mortality, conversion rate of critical diseases and safety of the two groups were observed. Results The WBC level in the observation group was obviously higher than that in the control group [（56.21 ±19.20） ×10^9/L vs（32.61±18.27）×109/L]（t=4.958,P=0.028）, and the N level in the observation group was obviously higher than that in the control group [（35.24±13.91）% vs（24.36±11.54）%]（t=3.352,P=0.031）; and the defervescence time in the observation group was obviously lower than that in the control group [（40.25±1.44）h vs（52.54±1.74）h]（t=30.267,P=0.002）, and the disappearance time of herpes/rash in the observation group was obviously lower than that in the control group[（6.01±0.3）h vs（7.38±0.5）h]（t=13.082,P=0.014）, and the incidence rate of conversion to critical diseases in the observation group and in the control group was respectively 6.25% and 13.33%（t=2.093,P=0.041）. Conclusion The reduning injection in treatment of hand-foot-and-mouth diseases can effectively adjust the indicators of blood routine test, and promote the improvement of clinical symptoms, which is conducive to the recovery of children.
作者
沈卫珍
刘忠
SHEN Wei-zhen;LIU Zhong(Department of Drug Instrument, Yangzhou Third People＇s Hospital, Yangzhou, Jiangsu Province, 225125 China)
出处
《系统医学》
2018年第2期144-146,149,共4页
Systems Medicine
关键词
热毒宁注射液
手足口病
疗效
Reduning injection
Hand-foot-and-mouth diseases
Curative effect
