摘要
"炎症学说"是有关糖尿病病理生理机制的崭新观点,该学说认为糖尿病是细胞因子介导的炎症反应,可引起血管内皮功能障碍导致血管病变的发生发展。其中氧化应激是共同机制,炎症是导致疾病持续发展的关键因素。成纤维细胞生长因子19(fibroblast growth factor 19,FGF19)是一种新的代谢调节因子,也是餐后在远端小肠合成、分泌并释放入血的肠促激素。FGF19除调控胆汁酸的肠肝循环外,也可调节糖脂代谢,且近年发现其还具有抗炎作用。FGF19与糖尿病炎症反应或氧化应激的相关性使其成为糖尿病及其并发症防治的新靶点。
＂Inflammation hypothesis＂ is a new viewpoint on the physiopathologic mechanism of diabetes mellitus, which suggestes that diabetes mellitus is inflammatory response by cytokine mediated and cause endothelial dysfunction, furthermore, and lead to the occurrence and development of vascular lesions. Oxidative stress is common mechanism and inflammation is the key factor in the sustainable development of disease. FGF19 is new metabolic molecule, which can be produced in the distal small intestine and secreted into the circulation as gut-derived hormone after feeding. In addition to controlling the enterohepatic circulation of bile acids, FGF19 also regulates systemic lipid and glucose metabolism. In recent years, some studies showed that FGF19 played an important role in resisting inflammatory response. FGF19 has become potentially important target in the prevention and treatment of diabetes mellitus and its complications.
作者
焦延延
姜崴
JIAO Yanyan;JIANG Wei(Department of Endocrinology, First Affiliated Hospital of Harbin Medical University, Harbin 150001, China)
出处
《临床与病理杂志》
2018年第3期623-627,共5页
Journal of Clinical and Pathological Research
基金
国家自然科学基金青年项目(81200585)~~
关键词
成纤维细胞生长因子19
糖尿病
血管病变
氧化应激
炎症
fibroblast growth factor 19
diabetes mellitus
vascular lesions
oxidative stress
inflammation
