摘要
目的:观察参芪降糖颗粒辅助门冬胰岛素注射液对妊娠期糖尿病患者临床疗效及妊娠结局的影响。方法:2014年9月—2016年9月本院妇产科接受治疗的190例妊娠期糖尿病患者,按随机数字表法分为观察组(95例)和对照组(95例),对照组予以门冬胰岛素注射液治疗,观察组在此基础上增加口服参芪降糖颗辅助治疗,观察两组治疗期间药物不良反应、门冬胰岛素用量和血糖达标患者达标时间,比较两组治疗后血糖及糖化血红蛋白水平,评价疗效、妊娠不良结局及围产期并发症发生情况。结果:治疗期间,观察组门冬胰岛素用量(38.6±4.4U/d)低于对照组(52.7±6.3U/d),血糖达标者达标时间(4.5±1.1d)短于对照组(7.6±1.8d)(P<0.05),药物副作用发生率(8.4%)与对照组(12.6%)无差异(P=0.116);治疗后,两组餐前、餐后2h血糖值和糖化血红蛋白水平均较治疗前下降(P<0.05),但两组间比较未见差异(P>0.05);观察组妊娠期糖尿病治疗总有效率(96.8%)高于对照组(85.3%)(P<0.05),剖宫产、早产和晚期流产发生率(30.5%、2.1%和3.2%)均低于对照组(44.2%、13.7%和11.6%),且围产期并发症发生率(7.4%)低于对照组(26.3%)(P<0.05)。结论:较单纯胰岛素补充治疗,参芪降糖颗联合门冬胰岛素注射液治疗方案,可提高妊娠期糖尿病患者的总体疗效水平,降低胰岛素使用量,缩短患者血糖达标时间,改善妊娠结局,降低围产期并发症的发生,且不会增加药物不良反应。
Objective：To observe the clinical effect of Shenqi Jiangtang granule combined with insulin aspart injection for treating women with gestational diabetes.Methods：190 women with gestational diabetes mellitus（GDM）in de-partment of gynecology and obstetrics of Zhoushan hospital were selected as research subjects from September 2014 to September 2016,and all the pregnant women were randomized divided into study group（95 cases）and control group（95 cases）according to the random number table.The pregnant women in control group were treated by insulin aspart injection only,and the pregnant women in study group were given oral administration of shenqi jiangtang granule ex-cept insulin aspart inieetion.The occurrence of adverse reactions of drugs during the treatment,the average dosage of insulin aspartate and the period of blood glucose up to standard of pregnant women in both groups were observed,and the blood glucose and glyeosylated hemoglobin level after treatment were compared between the two groups.And the curative effect,rate of adverse pregnant outcomes,and rate of perinatal complications were evaluated between the two groups.Results：During the treatment,the average amount of insulin aspart used of women in study group（38.6±4.4）IU/d was significant lower than that of women in control group（52.7±6.3）IU/d,and the time of blood glucose up to standard of women in study group（4.5± 1.1）d was significantly shorter than that of women（7.6±1.8）d in control group（P〈0.05）.There was no significant different in the incidence of adverse reactions of drugs between study group（8.4%）and control group（12.6%）（P =0.12）.After treatment,the levels of pre-prandial and postprandial 2h blood sugar and glycated hemoglobin of women were significant lower than those of women before the treatment in the both groups（P〈0.05）,but there was no significant different in levels of pre-prandial blood glucose,postprandial 2h blood glucose and glycated hemoglobin of women between the two groups（P〈0.05）.The total effective rate of gestational diabetes in study group（96.8%）was significantly higher than that in control group（85.3%）（P〈0.05）.The inci-dence of cesarean section,premature birth and abortion of women in study group（30.5%,2.1% and 3.2 %,respec-tively）were significantly lower than those of women in control group（44.2%,13.7 % and 11.6 %,respectively）（P〈0.05）,and the incidence of perinatal complications of women in study group（7.4%）was significantly lower than that of women in control group（26.30/00）（P〈0.05）.Conclusion：Insulin injection combined Shenqi jiangtang granule for treating women with GDM can significantly improve the overall effect,decrease the dosage of insulin injection,shorten the time of blood glucose up to standard,improve pregnancy outcomes,reduce rate of perinatal complications,and don＇t increase rate of adverse reactions of drugs.
作者
安艳芳
孙娜芬
AN Yanfang;SUN Nafen(Zhoushan hospital of Zhejiang Province, Zhejiang, 316000;Zhoushan Maternal and Child Health Care Hospital of Zhejiang Province.)
出处
《中国计划生育学杂志》
2018年第4期294-298,共5页
Chinese Journal of Family Planning
关键词
参芪降糖颗粒
门冬胰岛素注射液
妊娠期糖尿病
疗效
妊娠结局
Shenqi Jiangtang granule
Insulin aspart injection
Gestational diabetes, Curative effect
Pregnant outcome
