摘要
多发性骨髓瘤(MM)是一种好发于中老年人的不可治愈的恶性肿瘤,随着人口的老龄化,MM发病率呈逐年上升趋势。尽管目前放化疗联合手术等综合性治疗提高了MM患者5～10年生存率,但由于该病起病徐缓且早期无典型临床症状,使MM患者致畸率及致死率依然较高,因而对MM的早期诊治及预后显得尤为重要。最近证据表明,该病已被认为是一种多因素和多基因性疾病,且其基因位点的多态性很可能是MM发病的易感因素。进一步深入了解MM的发病与相关基因多态性的关系至关重要,本文归纳了近年来有关MM易感基因多态性的最新研究进展,并作一综述。
Multiple myeloma（MM） is a kind of non-curative malignancy in the middle-aged and elderly patients. It is shown that the incidence of the disease is increasing year by year due to the aging of the population. Although 5-to 10-year survival rate of MM patients received the combination of radiotherapy,chemotherapy and surgical treatment and other comprehensive treatment has been greatly improved,but due to the slow onset and early atypical clinical symptoms,the teratogenic rate and death rate of patients with MM is still high. Therefore,it is particularly important for the early diagnosis and prognosis of MM. Recent evidence suggests that the disease has been considered a multifactor and polygenic disorder,and the polymorphism of its gene loci is likely to be a susceptible factor in the pathogenesis of MM. Further understanding of the relationship between the pathogenesis of MM and related gene polymorphisms is very important. Therefore,the recent research progress on MM susceptibility gene polymorphisms in recent years is summarized and reviewed.
作者
廖林波
唐毓金
蓝常贡
农峰
梁俊卿
LIAO Linbo;TANG Yujin;LAN Changgong;NONG Feng;LIANG Junqing(Department of Orthopaedics, Affiliated Hospital of Youjiang Medical College for Nationalities, Baise 533000, Chin)
出处
《临床肿瘤学杂志》
CAS
北大核心
2018年第3期279-283,共5页
Chinese Clinical Oncology
基金
国家自然科学基金资助项目(81260315)
关键词
多发性骨髓瘤
易感性
基因多态性
Multiple myeloma（MM）
Susceptibility
Genetic polymorphisms
