摘要
目的:研究慢性心衰实验动物某些生化指标和心功能的变化,为慢性心衰的诊断提供依据。方法:使用阿霉素制备新西兰兔慢性心衰模型,将20只新西兰兔随机分为模型组(n=15)和对照组(n=5),分别耳缘静脉注射阿霉素(ADR)和生理盐水1 ml/kg,每周2次,共8周。随后进行心肌酶、颈动脉压、心电和心音信号的检测。结果:经统计学分析得知,两组的各项指标均有显著性差异(P<0.05)。结论:慢性心衰导致新西兰兔心肌受损,收缩功能和舒张功能下降,心脏储备指标有助于慢性心衰的诊断。
Objective： This article investigated the changes of some biochemical markers and cardiac function in chronic heart failure（ CHF）,and provided the basis for the diagnosis of CHF. Methods： New Zealand rabbit CHF model was established using adriamycin（ ADR）. Twenty New Zealand rabbits were randomly divided into model group（ n = 15） and control group（ n = 5）,injected with ADR and saline solution via the ear vein respectively,2 times a week,lasting for 8 weeks. After that,myocardial enzymes,carotid artery pressure,echocardiogram（ ECG） and phonocardiogram（ PCG） of all New Zealand rabbits were detected and recorded. Results： Compared with control group,all parameters of the model group were changed significantly（ P〈0.05）. Conclusion： CHF leads to myocardial damage in New Zealand rabbits,decreased systolic and diastolic function,cardiac reserve index can be used to assess cardiac function.
作者
周本梅
郭兴明
郑伊能
李宏全
ZHOU Ben-mei;GUO Xing-ming;ZHENG Yi-neng;LI Hong-quan(College of Bioengineering, Chongqing University, Chongqing Engineering Research Center for Medical Electronic Technology, Chongqing 400044, Chin)
出处
《中国应用生理学杂志》
CAS
CSCD
北大核心
2018年第1期74-77,共4页
Chinese Journal of Applied Physiology
基金
国家自然科学基金资助项目(31570003)
关键词
慢性心衰
新西兰兔
心功能
心脏储备指标
chronic heart failure
New Zealand rabbits
cardiac function
cardiac reserve index
