摘要
目的:观察通调带脉针刺对腹部肥胖型多囊卵巢综合征(PCOS)患者糖代谢、性激素、体脂参数的影响。方法:将腹部肥胖型PCOS患者随机分为治疗组30例和对照组28例。对照组予饮食运动监督,每周1次,治疗组在对照组基础上予针刺双侧带脉、天枢、大横、肾俞、次髎、归来、足临泣、外关,带脉、天枢连接电针仪(2Hz/100Hz,4~8mA),每周3次,均连续治疗12周。采用免疫荧光分析法观察治疗前后两组患者血清空腹胰岛素(FINS)、空腹血糖(FBG)、睾酮(T)、促黄体生成素(LH)、LH与卵泡刺激素比值(LH/FSH),计算胰岛素抵抗指数(HOMA-IR),测量体质量指数(BMI)、腰围(WC)、腰臀比(WHR)的变化。结果:两组治疗后FINS、HOMA-IR、T、LH、LH/FSH、BMI、WC、WHR均较治疗前明显下降(P<0.05,P<0.01),治疗组FINS、HOMA-IR、WC下降较对照组更显著(P<0.01,P<0.05)。结论:通调带脉针刺法可显著降低腹部肥胖型PCOS患者FINS、HOMA-IR、WC,在改善胰岛素抵抗状态方面优于饮食运动指导。
Objective To explore the therapeutic effect of acupuncture in the treatment of polycystic ovarian syndrome（PCOS）patients with abdominal obesity by regulating glucose metabolism,insulin resistance,sex hormones,etc.Methods Eligible PCOS volunteers were randomly divided into treatment group（n=30）and control group（n=28）.The treatment group received acupuncture therapy three times a week combined with diet control and exercise.EA（2 Hz/100 Hz,4-8 mA）was applied to bilateral Daimai（GB 26）and Tianshu（ST 25）for 20 min/time,and bilateral Daheng（SP 15）,Shenshu（BL 23）,Ciliao（BL 32）,Guilai（ST 29）,Zulinqi（GB 41）and Waiguan（SJ 5）were stimulated with filiform needles,with the needles retained for 20 min.Patients of the control group were asked to restrict intake of dietary calories（low fat,appropriate proteins,and high carbohydrate）and aerobic exercise（〉40 min/time）,3 times/week.The treatment duration lasted 12 weeks.Before and after the treatment,serum fasting insulin（FINS）,fasting blood-glucose（FBG）,Testosterone（T）,luteinizing hormone（LH）and follicle stimulating hormone（FSH）contents were assayed using immuno-fluorometry,the homeostasis model assessment of insulin resistance（HOMA-IR）and ratio of LH/FSH were calculated,and body mass index（BMI）,waist circumference（WC）and waist-hip ratio（WHR）were measured,separately.Results Comparison with their own individual pre-treatment,the levels of FINS,HOMAIR,T,LH,LH/FSH,BMI,WC and WHR（not FBG）in both control and treatment groups were significantly decreased（P〈0.05,P〈0.01）,and the levels of FINS,HOMA-IR and WC were significantly lower in the treatment group than in the control group（P〈0.01,P〈0.05）.No marked differences were found between two groups in the levels of FBG,T,LH,LH/FSH,BMI and WHR（P〉0.05）.Conclusion Acupuncture can effectively reduce FINS,HOMA-IR and WC levels in PCOS patients with abdominal obesity,down-regulating insulin resistance,which is significantly superior to simple diet control plus exercise.
作者
沈凌宇
梁翠梅
杨文津
潘良
李华
胡慧
SHEN Ling-yu;LIANG Cui-mei;YANG Wen-jin;PAN Liang;LI Hua;HU Hui(DepartmentofAcupuncture and Moxibus- tion, Dongfang Hospital Affiliated to Beijing University of Chinese Medicine, Beijing 100078, China)
出处
《针刺研究》
CAS
CSCD
北大核心
2018年第4期255-259,共5页
Acupuncture Research
基金
北京市科学技术委员会"首都临床特色应用研究"(No.Z 161100000516057)
北京中医药大学基本科研项目(No.2017-JYB-XS-153)
关键词
针刺
多囊卵巢综合征
腹型肥胖
饮食控制加运动
胰岛素抵抗
性激素
Acupuncture
Polycystic ovarian syndrome
Abdominal obesity
Diet control plus exercise
Insulin resistance
Sex hormones
