摘要
目的探究左乙拉西坦联合奥卡西平在小儿癫痫治疗中的效果。方法选取2015年7月～2017年7月莆田市涵江医院儿科收治的癫痫患儿100例为研究对象，随机分为观察组及对照组各50例。对照组接受奥卡西平治疗，观察组接受左乙拉西坦联合奥卡西平治疗，比较两组患儿的脑电图、认知功能变化和不良反应情况。结果观察组治疗有效率高于对照组，差异有统计学意义（P〈0．05）。治疗后两组语言智商、行为智商及总智商均高于治疗前，差异有统计学意义（P〈0．05）；观察组上述指标高于对照组，差异有统计学意义（P〈0．05）。结论采用左乙拉西坦联合奥卡西平治疗小儿癫痫疗效显著，可明显改善癫痫样放电，确保患儿认知功能正常发育，减少不良反应发生率，值得临床进一步推广使用。
Objective To investigate the clinical effect of levetiracetam combined with oxcarbazepine in the treatment of pediatric epilepsy.Methods A total of 100 children with epilepsy were collected in Hanjiang Hospital,Putian City,from July,2015 to July,2017,and randomly divided into observation group and control group（n=50 each group）.The children in control group only received oxcarbazepine treatment,and the children in observation group received levetiracetam combined with oxcarbazepine treatment.The electroencephalogram（EEG）,cognitive function and adverse reaction were compared between two groups.Results The therapeutic effective rate in observation group was significantly higher than that in control group（P〈0.05）.The language intelligence quotient,behavior intelligence quotient,and total intelligence quotient after treatment were all significantly higher than before treatment,and the aboved indexes in observation group were significantly higher than control group（P〈0.05）.Conclusion The levetiracetam combined with oxcarbazepine was more effective in the treatment of pediatric epilepsy,which could improve epileptiform discharges,keep the child patient cognitive function developing normally,and decrease the adverse reaction rate.
作者
蔡小勇
CAI Xiaoyong(Hanjiang Hospital of Putian City, Putian 351111, Fujian Province, China)
出处
《中国实用乡村医生杂志》
2018年第4期61-63,共3页
Chinese Practical Journal of Rural Doctor
关键词
左乙拉西坦
奥卡西平
小儿癫痫
效果分析
Levetiracetam
Oxcarbazepin
Pediatric Epilepsy
Effect Analysis
