摘要
目的探讨加味补中益气汤联合苦参素注射液对进展期胃癌术后患者血清可溶性白细胞介素-2受体(s IL-2R)、血管内皮生长因子(VEGF)水平变化及生存周期的影响。方法将86例进展期胃癌患者按随机数字表法分组,各43例。对照组术后予以常规化疗治疗,观察组术后在常规化疗基础上予以加味补中益气汤联合苦参素注射液治疗,均持续治疗6个周期(3周为1个治疗周期)。比较两组治疗前后血清s IL-2R、VEGF水平,并统计两组治疗效果、不良反应发生率、无进展生存期、总生存期。结果治疗后,与对照组比较,观察组血清s IL-2R、VEGF水平均降低(P<0.05);观察组总有效率53.49%(23/43)与对照组41.86%(18/43)比较,差异无统计学意义(P>0.05),但疾病控制率81.40%(35/43)高于对照组60.47%(26/43)(P<0.05);观察组胃肠道反应、肝功能损伤、血小板减少、肾功能损伤、骨髓抑制等不良反应发生率均低于对照组(P<0.05);观察组无进展生存期、总生存期均较对照组延长(P<0.05)。结论对行胃切除术治疗的进展期胃癌患者术后予以加味补中益气汤联合苦参素注射液治疗疗效肯定,可明显改善其血清s IL-2R、VEGF水平,延长其生存周期,降低不良反应发生率。
Objective To investigate the effect of modified Buzhong Yiqi decoction combined with oxymatrine injection on the changes of the levels of serum soluble interleukin-2 receptor（s IL-2 R）, vascular endothelial growth factor（VEGF）and survival period in the patients with postoperative advanced gastric cancer. Methods 86 patients with advanced gastric cancer were divided into two groups according to the random number method, with 43 cases in each group. The control group was given conventional chemotherapy after the surgery, and the observation group was given modified Buzhong Yiqi decoction combined with oxymatrine injection on the basis of the conventional chemotherapy. The treatment was for 6 cycles continuously（3 weeks were for 1 treatment cycle）. Levels of serum s IL-2 R and VEGF were compared between the two groups before and after treatment. The therapeutic effect, incidence rate of adverse reactions,progression-free survival and overall survival were compared and statistically analyzed between the two groups. Results After treatment, the levels of s IL-2 R and VEGF in the observation group were lower than those in the control group（P〈0.05）; the total effective rate in the observation group was 53.49%（23/43） compared with that of 41.86%（18/43） in the control group, with no statistically significant difference（P〉0.05）. However, the disease control rate was 81.40%（35/43）,higher than that in the control group（60.47%, 26/43）（P〈0.05）; the incidence rate of adverse reactions such as gastrointestinal reactions, liver function damage, thrombocytopenia, renal dysfunction and myelosuppression in the observation group was lower than that in the control group（P〈0.05）; progression-free survival and overall survival in the observation group were longer than those in the control group（P〈0.05）. Conclusion Modified Buzhong Yiqi decoction combined with oxymatrine injection in the treatment of patients with advanced gastric cancer undergoing gastrectomy has an exact efficacy, which can significantly improve the serum s IL-2 R and VEGF levels, prolong its life cycle, and reduce the incidence rate of adverse reactions.
作者
吴建业
周欣雯
丰银平
WU Jianye;ZHOU Xinwen;FENG Yinping(Lishui Hospital of TCM in Zhejiang Province, Lishui 323000, Chin)
出处
《中国现代医生》
2018年第10期5-7,11,共4页
China Modern Doctor
基金
浙江省中医药科技计划项目(2018ZB144)
