摘要
目的探究右归丸联合隔姜灸治疗阳虚寒凝型膝骨性关节炎的临床效果。方法选取东莞市第三人民医院2013年6月~2017年6月诊治的110例阳虚寒凝型膝骨性关节炎患者,采取随机数字表法将其分为对照组与试验组,各55例。对照组给予口服右归丸治疗,试验组给予右归丸联合隔姜灸治疗。比较两组患者治疗前后血清炎症活动指标、血清免疫学指标、Lequesne指数积分及阳虚证候评分。结果两组患者治疗后红细胞沉降率(ESR)、C反应蛋白(CRP)、人体28个关节功能评估(DAS28)等血清炎症活动指标,白细胞介素-1(IL-1)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)等血清免疫学指标以及Lequesne指数积分和阳虚证候评分均较治疗前明显降低(P<0.05),且试验组治疗后各项血清炎症活动指标、血清免疫学指标、Lequesne指数积分及阳虚证候评分均明显低于同期对照组,差异有统计学意义(P<0.05)。结论右归丸联合隔姜灸治疗阳虚寒凝型膝骨性关节炎效果显著,能够有效改善炎症症状,提高患者免疫力,缓解疼痛,安全性较高。
Objective To explore the clinical curative effect of Yougui Pills combined with ginger moxibustion in the treatment of knee osteoarthritis with syndrome of yang deficiency and coagulated cold. Methods One hundred and ten cases of knee osteoarthritis patients with syndrome of yang deficiency and coagulated cold treated in the Third People＇s Hospital of Dongguan City form June 2013 to June 2017 were selected and randomly divided into control group and experimental group by random number table method, with 55 cases in each group. The control group was given oral Yougui Pills, the experimental group was given Yougui Pills combined with ginger moxibustion. The serum inflammatory activity indicators, serum immunological indices, and the scores of Lequesne index and yang deficiency syndrome of the two groups before and after treatment were compared. Results After treatment, the serum inflammatory activity indicators of erythrocyte sedimentation rate（ESR）, C-reactive protein（CRP） and 28 human body joint function assessment（DAS28）, the serum immunological indices of interleukin 1（IL-1）, interleukin 6（IL-6）, tumor necrosis factor alpha（TNF-α） and the scores of Lequesne index and yang deficiency syndrome in the two groups were significantly lower than those before treatment（P〈0.05）, and the serum inflammatory activity indicators, serum immunological indices,the scores of Lequesne index and yang deficiency syndrome in the experimental group after treatment were all significantly lower than those of control group at the same period, the differences were all statistically significant（P〈0.05）.Conclusion Yougui Pills combined with ginger moxibustion in the treatment of knee osteoarthritis with syndrome of yang deficiency and coagulated cold has remarkable curative effects, which can significantly improve the inflammatory symptoms and immunity, relieve pain, with high safety.
作者
邵洁琦
曾志江
杨敏
陆向然
钟秋生
SHAO Jieqi, ZENG Zhijiang, YANG Min ,LU Xiangran, ZHONG Qiusheng(Internal Medicine Department of Traditional Chinese Medicine, the Third People＇s Hospital of Dongguan City, Guangdong Province, Dongguan 523326, Chin)
出处
《中国医药导报》
CAS
2018年第10期106-109,共4页
China Medical Herald
基金
广东中医药局科研项目(20162143)
关键词
右归丸
隔姜灸
阳虚寒凝型
膝骨性关节炎
Yougui Pills
Ginger moxibustion
Syndrome of yang deficiency and coagulated cold
Knee osteoarthritis
