摘要
目的探讨胰岛样生长因子1(IGF-1)、超敏C反应蛋白(hs-CRP)、氮末端B型脑钠肽(NT-pro BNP)与老年2型糖尿病患者左心室肥厚的临床关系。方法选取2015年6月~2017年2月邢台市第二医院(以下简称"我院")收治的老年2型糖尿病患者163例,其中伴左心室肥厚患者74例(肥厚组),未伴任何并发症者89例(糖尿病组)。另选取同期我院健康体检者79例(对照组)。对比心脏左心室舒张末内径(LVIDd)、收缩末内径(LVIDs)、舒张末后壁厚度(LVPWD)及舒张末室间隔厚度(IVST)、左心室重量指数(LVMI)及血清IGF-1、hs-CRP、NTproBNP水平,并分析血清指标与肥厚组左心室肥厚的关系。结果肥厚组及糖尿病组的LVIDd、LVIDs、LVPWD、IVST、LVMI及血清hs-CRP、NT-proBNP水平均明显高于对照组(P<0.05),且肥厚组明显高于糖尿病组(P<0.05);肥厚组和对照组的血清IGF-1均明显高于糖尿病组(P<0.05),且肥厚组明显高于对照组(P<0.05);IGF-1、hsCRP及NT-proBNP水平均与LVIDd、LVIDs、LVPWD、IVST及LVMI呈正相关(P<0.05)。结论血清IGF-1、hsCRP及NT-proBNP水平在老年2型糖尿病伴左心室肥厚患者中均显著升高,与左心室肥厚关系密切。
Objective To investigate the clinical relationships between islet growth factor 1（IGF-1）, high sensitivity C reactive protein（hs-CRP） and N-terminal B type natriuretic peptide（NT-pro BNP） and left ventricular hypertrophy in elderly patients with type 2 diabetes. Methods From June 2015 to February 2017, 163 elderly patients with type 2 diabetes were selected in the Second Hospital of Xingtai（＂our hospital＂ for short）, including 74 patients with left ventricular hypertrophy（hypertrophy group） and 89 patients without any complications（diabetes group）. During the same period, 79 healthy persons in our hospital were selected（control group）. The left ventricular end diastolic diameter（LVIDd）, systolic diameter（LVIDs）, end diastolic posterior wall thickness（LVPWD）, end diastolic ventricular septal thickness（IVST）, left ventricular mass indexes（LVMI） and the levels of serum IGF-1, hs-CRP and NT-pro BNP were compared, then the relationships between serum indexes and left ventricular hypertrophy of hypertrophy group were analyzed. Results The LVIDd, LVIDs, LVPWD, IVST, LVMI and the serum levels of hs-CRP and NT-pro BNP of the hypertrophy group and diabetes group were significantly higher than those of the control group（P〈0.05）, of which the hypertrophy group were significantly higher than those of the diabetes group（P〈0.05）. The serum levels of IGF-1 of the hypertrophy group and the control group were significantly higher than those of the diabetes group（P〈0.05）, of which the hypertrophy group was significantly higher than that of the control group（P〈0.05）. The levels of IGF-1, hs-CRP and NT-pro BNP were positively related to LVIDd, LVIDs, LVPWD, IVST and LVMI（P〈0.05）. Conclusion The serum levels of IGF-1, hs-CRP and NT-pro BNP in left ventricular hypertrophy in elderly patients with type 2 diabetes mellitus are significantly increased, which have closed relationships with left ventricular hypertrophy.
作者
郭春霞
付丽坤
李默
李佳秀
王亚飞
宋华
GUO Chunxia, FU Likun, LI Mo, LI Jiaxiu, WANG Yafei, SONG Hua(Internal Medicine, the Second Hospital of Xingtai, Hebei Province, Xingtai 054001, Chin)
出处
《中国医药导报》
CAS
2018年第11期120-122,142,共4页
China Medical Herald
基金
河北省邢台市科技局科技计划项目(2017ZC072)
关键词
胰岛样生长因子1
超敏C反应蛋白
氮末端B型脑钠肽
2型糖尿病
左心室肥厚
Islet like growth factor 1
Hypersensitive C reactive protein
Nitrogen terminal B brain natriuretic peptide
Type 2 diabetes
Left ventricular hypertrophy
