摘要
目的分析西藏高原地区胆囊结石的危险因素。方法研究对象为2017年4月1日-15日在日喀则市人民医院进行门诊空腹超声检查的患者254例,根据超声检查结果,将研究对象分为胆囊结石组(45例)和对照组(209例)。对全部研究对象进行问卷调查、体格检查及检查结果分析。正态分布的计量资料组间比较采用t检验,非正态分布的计量资料组间比较采用MannWhitney U检验;计数资料组间比较采用χ~2检验或Fisher确切概率法;胆囊结石的危险因素分析采用logistic回归分析。结果胆囊结石组和对照组之间,年龄、饮酥油茶量、收缩压、性别、民族、文化程度、吸烟、遗传病史、HBs Ag等15个变量差异有统计学意义(P值均<0.05)。进一步采用单因素和多因素logistic回归分析,结果显示,女性[比值比(OR)=3.765,95%可信区间(95%CI):1.742~8.138]、遗传病史(OR=5.995,95%CI:1.666~21.580)、文化程度较低(OR=2.907,95%CI:1.342~6.295)、收缩压(OR=1.022,95%CI:1.004~1.041)和酥油茶饮用量(OR=1.082,95%CI:1.007~1.163)是西藏高原地区患胆囊结石的独立危险因素(P值均<0.05)。结论西藏地区胆囊结石的发生可能与性别、酥油茶饮用量、遗传因素、文化程度和收缩压有关。为当地胆囊结石的预防、早期诊断和治疗提供了信息和线索。
Objective To investigate the risk factors for gallstones in Tibetan Plateau.Methods A total of 254 patients who underwent ultrasound examination in a fasting state in Shigatse People’s Hospital from April 1 to 15,2017 were enrolled,and according to the results of ultrasound examination,these patients were divided into gallstone group with 45 patients and control group with 209 patients.A questionnaire survey,a physical examination,and a result analysis were performed for all patients.The t-test was used for comparison of normally distributed continuous data between groups,and the Mann-Whitney U test was used for comparison of non-normally distributed continuous data between groups; the chi-square test or the Fisher’s exact test was used for comparison of categorical data between groups; a logistic regression analysis was performed to identify risk factors for gallstones.Results There were significant differences between the gallstone group and the control group in 15 variables including age,drinking amount of Tibetan butter tea,systolic pressure,sex,ethnicity,education level,smoking,a history of inherited diseases,and HBs Ag（all P 〈 0.05）.The univariate and multivariate analyses showed that female sex（odds ratio [OR]= 3.765,95% confidence interval [CI]：1.742-8.138）,a history of inherited diseases（OR = 5.995,95% CI：1.666-21.580）,a low education level（OR = 2.907,95% CI：1.342-6.295）,systolic pressure（OR = 1.022,95% CI：1.004-1.041）,and drinking amount of Tibetan butter tea（OR = 1.082,95% CI：1.007-1.163） were independent risk factors for gallstones in Tibetan Plateau（all P 〈 0.05）.Conclusion Sex,drinking amount of Tibetan butter tea,genetic factors,education level,and systolic pressure may be associated with the development of gallstones in Tibetan Plateau,which provides important information and clues for the prevention,early diagnosis,and treatment of gallstones in this area.
作者
杨波
侯永志
王翔飞
德吉
宾业健
白珍
米玛
YANG Bo;HOU Yongzhi;WANG Xiangfei;et al(Department of Medical Ultrasonics, Huadong Sanatorium, Shanghai Tibet -supporting Medical Team, Wuxi, Jiangsu 214065, China)
出处
《临床肝胆病杂志》
CAS
北大核心
2018年第4期789-794,共6页
Journal of Clinical Hepatology
基金
西藏自治区自然科学基金(2016ZR-QY-10)
